Author: "Fischer, Melissa" / Journal: blood - Searchworks@Jio Institute Digital Library Search Results

Author: Silver, Alexander J., primary, Brown, Donovan J., additional, Arrate, Maria P., additional, Wang, Yu, additional, Fischer, Melissa A., additional, Bhat, Pawan, additional, Heimlich, J. Brett, additional, Bick, Alexander G., additional, Ferrell, P. Brent, additional, Xu, Yaomin, additional, and Savona, Michael R., additional
Published: 2022
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Author: Ramsey, Haley E., primary, Arrate, Maria, additional, Fuller, Londa, additional, Gorska, Agnieszka E., additional, Boyd, Kelli, additional, Fischer, Melissa A., additional, Oganesian, Aram, additional, Azab, Mohammad, additional, and Savona, Michael R., additional
Published: 2019
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Author: Fischer, Melissa A., primary, Arrate, Maria, additional, Childress, Merrida A, additional, Smith, Brianna N, additional, Song, Yuanbin, additional, Gbyli, Rana, additional, Stricker, Thomas, additional, Halene, Stephanie, additional, and Savona, Michael R., additional
Published: 2019
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Author: Ramsey, Haley, primary, Zhang, Susu, additional, Zhao, Yue, additional, Fischer, Melissa Ann, additional, Gorska, Agnieszka Ewa, additional, Arrate, Maria, additional, Fuller, Londa, additional, Greenwood, Dalton, additional, Stubbs, Matthew C., additional, Liu, Phillip, additional, Rathmell, Jeffrey C, additional, Hiebert, Scott, additional, and Savona, Michael R., additional
Published: 2018
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Author: Fischer, Melissa A., primary, Friedlander, Sharon, additional, Hogdal, Leah, additional, Arrate, Pia, additional, Chang, Hua, additional, Kashyap, Trinayan, additional, Argueta, Christian, additional, Klebanov, Boris, additional, Senapedis, William, additional, Baloglu, Erkan, additional, Lee, Margaret S., additional, Shacham, Sharon, additional, and Savona, Michael R., additional
Published: 2016
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Author: Silver, Alexander J, Brown, Donovan J, Vlasschaert, Caitlyn, Bhat, Pawan, Puddu, Fabio, Van Amburg, Joseph C, Villaume, Matthew T, Fischer, Melissa A, Arrate, Maria P, Wang, Yu, Scotcher, Jamie, Stengel, Kristy, Smith, Brianna Nicole, Sharber, Brian, Potts, Chad R, Consugar, Mark, Heimlich, Jonathan Brett, Xu, Yaomin, Ferrell, P. Brent, Bick, Alexander G., and Savona, Michael R.
Abstract: Clonal hematopoiesis (CH) is an age-associated phenomenon which is known to increase the risk for hematologic malignancy and cardiovascular disease. The most commonly mutated gene in CH is de novoDNA methyltransferase DNMT3A. R882H and R882C are the most common hotspot mutations in this gene, and these mutations are commonly grouped together in interpretation of clinical data even though in vitroexperiments suggest divergence in their biochemical consequences. Here, we used CRISPR knock-in of primary hematopoietic stem and progenitor cells (HSPCs) along with population data from the UK Biobank (UKB) to evaluate the extent to which R882H and R882C differentially predispose to inflammatory phenotypes.
Published: 2023
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Author: Kishtagari, Ashwin, Fischer, Melissa A, Seegmiller, Adam C., Padron, Eric, Cluzeau, Thomas, Xicoy, Blanca, Garciaz, Sylvain, Diez-Campelo, Maria, Corty, Robert Wallace, Moyo, Tamara K., Braun, Theodore P, Mendler, Jason H., Patnaik, Mrinal M., Mason, Emily Ferguson, Shaver, Aaron C., Pfeilstoecker, Michael, Durivage, Henry, Medeghri, Nadjat, Anderson, Barry, Platzbecker, Uwe, Fenaux, Pierre, Santini, Valeria, and Savona, Michael R.
Abstract: Background:
Published: 2023
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Author: Silver, Alexander J., Brown, Donovan J., Arrate, Maria P., Wang, Yu, Fischer, Melissa A., Bhat, Pawan, Heimlich, J. Brett, Bick, Alexander G., Ferrell, P. Brent, Xu, Yaomin, and Savona, Michael R.
Published: 2022
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