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1. The old and the current concepts of the renal handling of extracorpuscular plasma Hgb are briefly reviewed. 2. Studies are presented on the starch gel electrophoretic behavior of Mb alone and Mb in serum. 3. It is suggested that Mb is not bound by Hp, known to bind Hgb, and that this constitutes the reason for the "low renal threshold" of Mb as compared to that of Hgb.

1. Two of three female patients with the autoerythrocyte syndrome were tested for sensitivity to various components of the erythrocyte membrane. One was consistently sensitive to purified phosphatidyl serine. 2. It is suggested that in at least one patient with autoerythrocyte purpura the phosphatidyl serine of the red cell membrane may play a role in the pathogenesis of the purpuric lesions. 3. It is likely that a broad spectrum of autosensitivity-type purpuric disorders exists in women with complex emotional problems. The threshold of reactivity may be modified by the psyche.