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33 results on '"Di Ianni, Mauro"'

1. Dosing Pattern of Ruxolitinib (RUX) in Patients with Myelofibrosis (MF) in Italy: Results from a Prospective Observational Study (ROMEI)

Author

Breccia, Massimo, primary, Guglielmelli, Paola, additional, Mendicino, Francesco, additional, Malato, Alessandra, additional, Palumbo, Giuseppe A., additional, Selleri, Carmine, additional, Cilloni, Daniela, additional, Mazza, Patrizio, additional, Siragusa, Sergio, additional, Abruzzese, Elisabetta, additional, Martelli, Maurizio, additional, Benevolo, Giulia, additional, Rinaldi, Erminia, additional, Crugnola, Monica, additional, Rupoli, Serena, additional, Pavone, Vincenzo, additional, Bonifacio, Massimiliano, additional, Pane, Fabrizio, additional, Carli, Giuseppe, additional, Langella, Maria, additional, Bruno Ventre, Marta, additional, Elli, Elena Maria, additional, Impera, Stefana, additional, Liberati, Anna Marina, additional, Di Renzo, Nicola, additional, Martino, Bruno, additional, Sportoletti, Paolo, additional, Tiribelli, Mario, additional, Binotto, Gianni, additional, Annunziata, Mario, additional, Di Ianni, Mauro, additional, La Nasa, Giorgio, additional, Falcone, Antonietta Pia, additional, Leanza, Rossana, additional, Volpe, Antonio, additional, Gherlinzoni, Filippo, additional, De Stefano, Valerio, additional, Vallisa, Daniele, additional, Leonetti Crescenzi, Sabrina, additional, Cavazzini, Francesco, additional, Ricco, Alessandra, additional, Barberio, Carmela, additional, Misto, Alessandra, additional, Passamonti, Francesco, additional, and Palandri, Francesca, additional

Published
2022
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3. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

Author

Di Ianni, Mauro, Falzetti, Franca, Carotti, Alessandra, Terenzi, Adelmo, Castellino, Flora, Bonifacio, Elisabetta, Del Papa, Beatrice, Zei, Tiziana, Ostini, Roberta Iacucci, Cecchini, Debora, Aloisi, Teresa, Perruccio, Katia, Ruggeri, Loredana, Balucani, Chiara, Pierini, Antonio, Sportoletti, Paolo, Aristei, Cynthia, Falini, Brunangelo, Reisner, Yair, Velardi, Andrea, Aversa, Franco, and Martelli, Massimo F.

Published
2011
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4. Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity

Author

Cunha, Cristina, Di Ianni, Mauro, Bozza, Silvia, Giovannini, Gloria, Zagarella, Silvia, Zelante, Teresa, D'Angelo, Carmen, Pierini, Antonio, Pitzurra, Lucia, Falzetti, Franca, Carotti, Alessandra, Perruccio, Katia, Latgé, Jean-Paul, Rodrigues, Fernando, Velardi, Andrea, Aversa, Franco, Romani, Luigina, and Carvalho, Agostinho

Published
2010
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5. CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice

Author

Martelli, Maria Paola, Pettirossi, Valentina, Thiede, Christian, Bonifacio, Elisabetta, Mezzasoma, Federica, Cecchini, Debora, Pacini, Roberta, Tabarrini, Alessia, Ciurnelli, Raffaella, Gionfriddo, Ilaria, Manes, Nicla, Rossi, Roberta, Giunchi, Linda, Oelschlägel, Uta, Brunetti, Lorenzo, Gemei, Marica, Delia, Mario, Specchia, Giorgina, Liso, Arcangelo, Di Ianni, Mauro, Di Raimondo, Francesco, Falzetti, Franca, Del Vecchio, Luigi, Martelli, Massimo F., and Falini, Brunangelo

Published
2010
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8. A randomized double-blind trial of 3 aspirin regimens to optimize antiplatelet therapy in essential thrombocythemia

Author

Rocca, Bianca, primary, Tosetto, Alberto, primary, Betti, Silvia, primary, Soldati, Denise, primary, Petrucci, Giovanna, primary, Rossi, Elena, primary, Timillero, Andrea, primary, Cavalca, Viviana, primary, Porro, Benedetta, primary, Iurlo, Alessandra, primary, Cattaneo, Daniele, primary, Bucelli, Cristina, primary, Dragani, Alfredo, primary, Di Ianni, Mauro, primary, Ranalli, Paola, primary, Palandri, Francesca, primary, Vianelli, Nicola, primary, Beggiato, Eloise, primary, Lanzarone, Giuseppe, primary, Ruggeri, Marco, primary, Carli, Giuseppe, primary, Elli, Elena Maria, primary, Carpenedo, Monica, primary, Randi, Maria Luigia, primary, Bertozzi, Irene, primary, Paoli, Chiara, primary, Specchia, Giorgina, primary, Ricco, Alessandra, primary, Vannucchi, Alessandro Maria, primary, Rodeghiero, Francesco, primary, Patrono, Carlo, primary, and De Stefano, Valerio, primary

Published
2020
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9. Adoptive Immunotherapy with Regulatory and Conventional T Cells in Haploidentical Transplantation Primes Dendritic Cells to Promote T Cell Alloreactivity in the Bone Marrow and Tolerance in the Periphery

Author

Di Ianni, Mauro, primary, Giancola, Raffaella, additional, Baldoni, Stefano, additional, Ulbar, Francesca, additional, Del Papa, Beatrice, additional, Santarone, Stella, additional, Natale, Annalisa, additional, Olioso, Paola, additional, Di Bartolomeo, Paolo, additional, Bonfini, Tiziana, additional, Accorsi, Patrizia, additional, Sportoletti, Paolo, additional, Carotti, Alessandra, additional, Pierini, Antonio, additional, Ruggeri, Loredana, additional, Falzetti, Franca, additional, Martelli, Massimo Fabrizio, additional, and Velardi, Andrea, additional

Published
2019
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10. Regulatory T Cell Adoptive Immunotherapy Promotes B Cell Immunity after Haploidentical Transplantation

Author

Piccinelli, Sara, primary, Mancusi, Antonella, additional, Hoxha, Eni, additional, Ruggeri, Loredana, additional, Falzetti, Franca, additional, Carotti, Alessandra, additional, Terenzi, Adelmo, additional, Bonato, Samanta, additional, Paradiso, Matteo, additional, Zei, Tiziana, additional, Iacucci Ostini, Roberta, additional, Bigerna, Barbara, additional, Falini, Brunangelo, additional, Di Ianni, Mauro, additional, Martelli, Massimo Fabrizio, additional, Velardi, Andrea, additional, and Pierini, Antonio, additional

Published
2019
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11. Pomalidomide and Dexamethasone for Relapsed/Refractory Multiple Myeloma: A Single-Center Real Life Experience

Author

Cantò, Chiara, primary, Ranucci, Elena, additional, Pulini, Stefano, additional, Santoleri, Fiorenzo, additional, Morelli, Anna Maria, additional, Fioritoni, Francesca, additional, Falorio, Simona, additional, Torti, Lorenza, additional, Spadano, Antonio, additional, D'Aloisio, Marianna, additional, Di Ianni, Mauro, additional, Santarone, Stella, additional, and Di Bartolomeo, Paolo, additional

Published
2018
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12. How Adoptive Immunotherapy with Conventional T and Regulatory T Cells Exerts a Gvl Effect without GvHD, after Haploidentical Hematopoietic Transplantation

Author

Ruggeri, Loredana, primary, Carotti, Alessandra, additional, Pierini, Antonio, additional, Falzetti, Franca, additional, Terenzi, Adelmo, additional, Urbani, Elena, additional, Lucia, Amico, additional, Tricarico, Sara, additional, Piccinelli, Sara, additional, Massei, Maria Speranza, additional, Ciardelli, Sara, additional, Di Ianni, Mauro, additional, Zei, Tiziana, additional, Iacucci Ostini, Roberta, additional, Lancellotta, Valentina, additional, Saldi, Simonetta, additional, Minelli, Olivia, additional, Tognellini, Rita, additional, Merluzzi, Mara, additional, Marchesi, Mauro, additional, Caniglia, Maurizio, additional, Aristei, Cynthia, additional, Falini, Brunangelo, additional, Martelli, Massimo Fabrizio, additional, and Velardi, Andrea, additional

Published
2018
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13. How the Real-Life Diagnostic and Therapeutic Approach Changed in the Last Two Decades in the Thrombocythemic Patients with Ph- Negative Myeloproliferative Neoplasm. Report on 2388 Subjects of the Registro Italiano Trombocitemie (RIT)

Author

Gugliotta, Luigi, primary, Iurlo, Alessandra, additional, Gugliotta, Gabriele, additional, Tieghi, Alessia, additional, Canafoglia, Lucia, additional, Palmieri, Raffaele, additional, Pasciolla, Crescenza, additional, Vianelli, Nicola, additional, Ragionieri, Riccardo, additional, Rinaldi, Erminia, additional, Usala, Emilio, additional, La Nasa, Giorgio, additional, Perra, Alessandra, additional, Tagariello, Giuseppe, additional, Maschio, Nilla, additional, Cacciola, Emma, additional, Cacciola, Rossella Rosaria, additional, Bergamaschi, Micaela, additional, Da Col, Anna, additional, Rago, Angela, additional, Rizzo, Lorenzo, additional, Spina, Francesco, additional, Cattaneo, Daniele, additional, Lambertenghi, Daniela, additional, Casoria, Aniello, additional, Langella, Maria, additional, Randi, Maria Luigia, additional, Cosi, Elisabetta, additional, Crugnola, Monica, additional, Masselli, Elena, additional, Ranalli, Paola, additional, Garozzo, Giovanni, additional, Codeluppi, Katia, additional, Villani, Oreste, additional, Ferrara, Grazia, additional, Santoro, Cristina, additional, Scalzulli, Potito Rosario, additional, Ricciotti, Manlio, additional, Appolloni, Viviana, additional, Candoni, Anna, additional, Luraschi, Annalisa, additional, Serena, Rupoli, additional, DI Ianni, Mauro, additional, Caocci, Giovanni, additional, Lanza, Francesco, additional, Orofino, Nicola, additional, Rumi, Elisa, additional, Dragani, Alfredo, additional, Martino, Bruno, additional, Liberati, Anna Marina, additional, Santoro, Umberto, additional, and Vannucchi, Alessandro M., additional

Published
2016
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14. Patients with Unexplained Thrombosis Require a Prompt Investigation to Search a Chronic Myeloproliferative Neoplasm (MPN), Even If Platelet Count Is <600x109/L. Analysis on 129 Patients from Registro Italiano Trombocitemie (RIT)

Author

Benevolo, Giulia, primary, Iurlo, Alessandra, additional, Gugliotta, Gabriele, additional, Tieghi, Alessia, additional, Gaidano, Gianluca, additional, Tagariello, Giuseppe, additional, Martino, Bruno, additional, Di Ianni, Mauro, additional, Scalzulli, Potito Rosario, additional, Martinelli, Vincenzo, additional, Santoro, Umberto, additional, Beggiato, Eloise, additional, Randi, Maria Luigia, additional, Specchia, Giorgina, additional, Passamonti, Francesco, additional, Vannucchi, Alessandro M., additional, Vitolo, Umberto, additional, and Gugliotta, Luigi, additional

Published
2015
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18. Tregs Suppress GvHD at the Periphery and Unleash the Gvl Effect in the Bone Marrow

Author

Ruggeri, Loredana, primary, Di Ianni, Mauro, additional, Urbani, Elena, additional, Mancusi, Antonella, additional, Falzetti, Franca, additional, Carotti, Alessandra, additional, Terenzi, Adelmo, additional, Massei, Maria Speranza, additional, Amico, Lucia, additional, Zei, Tiziana, additional, Iacucci, Roberta, additional, Martelli, Massimo Fabrizio, additional, and Velardi, Andrea, additional

Published
2014
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19. HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse

Author

Martelli, Massimo F., primary, Di Ianni, Mauro, additional, Ruggeri, Loredana, additional, Falzetti, Franca, additional, Carotti, Alessandra, additional, Terenzi, Adelmo, additional, Pierini, Antonio, additional, Massei, Maria Speranza, additional, Amico, Lucia, additional, Urbani, Elena, additional, Del Papa, Beatrice, additional, Zei, Tiziana, additional, Iacucci Ostini, Roberta, additional, Cecchini, Debora, additional, Tognellini, Rita, additional, Reisner, Yair, additional, Aversa, Franco, additional, Falini, Brunangelo, additional, and Velardi, Andrea, additional

Published
2014
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20. HLA-Haploidentical Stem Cell Transplantation with Treg and Tcon Adoptive Immunotherapy promotes a Strong Graft-Versus-Leukemia Effect

Author

Di Ianni, Mauro, primary, Ruggeri, Loredana, additional, Falzetti, Franca, additional, Carotti, Alessandra, additional, Terenzi, Adelmo, additional, Massei, Maria Speranza, additional, Amico, Lucia, additional, Pierini, Antonio, additional, Velardi, Andrea, additional, and Martelli, Massimo Fabrizio, additional

Published
2013
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22. Adoptive Immunotherapy with Tregs and Tcons Ensures Low TRM and a Low Incidence of Post Transplant Leukaemia Relapse After HLA Haploidentical Transplants for Acute Leukemia

Author

Di Ianni, Mauro, primary, Falzetti, Franca, additional, Carotti, Alessandra, additional, Terenzi, Adelmo, additional, Ruggeri, Loredana, additional, Antonio, Pierini, additional, de Fazio, Vincenza, additional, Zoi, Valentina, additional, Massei, Maria Speranza, additional, Reisner, Yair, additional, Velardi, Andrea, additional, Aversa, Franco, additional, and Martelli, Massimo Fabrizio, additional

Published
2011
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30. CD34+cells from AML with mutated NPM1harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice

Author

Martelli, Maria Paola, Pettirossi, Valentina, Thiede, Christian, Bonifacio, Elisabetta, Mezzasoma, Federica, Cecchini, Debora, Pacini, Roberta, Tabarrini, Alessia, Ciurnelli, Raffaella, Gionfriddo, Ilaria, Manes, Nicla, Rossi, Roberta, Giunchi, Linda, Oelschlägel, Uta, Brunetti, Lorenzo, Gemei, Marica, Delia, Mario, Specchia, Giorgina, Liso, Arcangelo, Di Ianni, Mauro, Di Raimondo, Francesco, Falzetti, Franca, Del Vecchio, Luigi, Martelli, Massimo F., and Falini, Brunangelo

Abstract

Acute myeloid leukemia (AML) with mutated NPM1shows distinctive biologic and clinical features, including absent/low CD34 expression, the significance of which remains unclear. Therefore, we analyzed CD34+cells from 41 NPM1-mutated AML. At flow cytometry, 31 of 41 samples contained less than 10% cells showing low intensity CD34 positivity and variable expression of CD38. Mutational analysis and/or Western blotting of purified CD34+cells from 17 patients revealed NPM1-mutated gene and/or protein in all. Immunohistochemistry of trephine bone marrow biopsies and/or flow cytometry proved CD34+leukemia cells from NPM1-mutated AML had aberrant nucleophosmin expression in cytoplasm. NPM1-mutated gene and/or protein was also confirmed in a CD34+subfraction exhibiting the phenotype (CD34+/CD38−/CD123+/CD33+/CD90−) of leukemic stem cells. When transplanted into immunocompromised mice, CD34+cells generated a leukemia recapitulating, both morphologically and immunohistochemically (aberrant cytoplasmic nucleophosmin, CD34 negativity), the original patient's disease. These results indicate that the CD34+fraction in NPM1-mutated AML belongs to the leukemic clone and contains NPM1-mutated cells exhibiting properties typical of leukemia-initiating cells. CD34−cells from few cases (2/15) also showed significant leukemia-initiating cell potential in immunocompromised mice. This study provides further evidence that NPM1mutation is a founder genetic lesion and has potential implications for the cell-of-origin and targeted therapy of NPM1-mutated AML.

Published
2010
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31. Low-Toxicity/High-Efficacy HLA Haploidentical Transplantation for Elderly/Unfit Patients with Acute Leukemia

Author

Velardi, Andrea, Carotti, Alessandra, Falzetti, Franca, Terenzi, Adelmo, Ruggeri, Loredana, Pierini, Antonio, Piccinelli, Sara, Tricarico, Sara, Lucia, Amico, Casarola, Genni, Lancillotta, Valentina, Saldi, Simonetta, Di Ianni, Mauro, Aristei, Cynthia, and Martelli, Massimo Fabrizio

Abstract

Allogeneic hematopoietic transplantation is the most powerful therapy for patients with acute leukemia at high risk of relapse. For HLA haploidentical transplantation, we recently applied a protocol consisting of a high-intensity TBI-based conditioning regimen and a peripheral blood CD34+ hematopoietic stem cell graft combined with the adoptive transfer of naturally occurring regulatory T cells (Tregs) and conventional T cells (Tcons). No post-transplant pharmacologic immune suppressive GvHD prophylaxis was given. Such a protocol was associated with remarkably low GvHD and relapse rates (Martelli MF et al., Blood. 124:638-644, 2014; reviewed in Mancusi A et al., Blood 128:2616-2623, 2016).

Published
2017
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32. Secondary Solid Cancer Following Hematopoietic Cell Transplantation in Patients with Thalassemia Major

Author

Pepe, Alessia, Meloni, Antonella, Santarone, Stella, Natale, Annalisa, Di Ianni, Mauro, Pistoia, Laura, Cuccia, Liana, Spasiano, Anna, Lisi, Roberto, and Di Bartolomeo, Paolo

Abstract

Hematopoietic cell transplant (HCT) recipients have a substantial risk of developing secondary solid cancers (SSC). There is limited information about the incidence of SSC following HCT for patients with thalassemia major (TM).

Published
2017
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