Author: "Di Cataldo, Andrea" / Journal: blood - Searchworks@Jio Institute Digital Library Search Results

Author: Lo Nigro, Luca, primary, Barresi, Vincenza, additional, Andriano, Nellina, additional, Pulvirenti, Giulio, additional, Spampinato, Giorgia, additional, Bonaccorso, Paola, additional, Iachelli, Valeria, additional, La Rosa, Manuela, additional, Cannata, Emanuela, additional, Di Cataldo, Andrea, additional, Russo, Giovanna, additional, and Condorelli, Daniele, additional
Published: 2018
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Author: Andriano, Nellina, primary, Iachelli, Valeria, additional, Bonaccorso, Paola, additional, La Rosa, Manuela, additional, Cannata, Emanuela, additional, Miraglia, Vito, additional, D'Amico, Salvatore, additional, Di Cataldo, Andrea, additional, Russo, Giovanna, additional, and Lo Nigro, Luca, additional
Published: 2016
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Author: Iachelli, Valeria, primary, Andriano, Nellina, additional, Bonaccorso, Paola, additional, La Rosa, Manuela, additional, Cannata, Emanuela, additional, Samperi, Piera, additional, La Spina, Milena, additional, Di Cataldo, Andrea, additional, Russo, Giovanna, additional, and Lo Nigro, Luca, additional
Published: 2016
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Author: Bonaccorso, Paola, primary, La Rosa, Manuela, additional, Andriano, Nellina, additional, Iachelli, Valeria, additional, Cannata, Emanuela, additional, Bellia, Francesco, additional, Licciardello, Marinella, additional, Di Cataldo, Andrea, additional, Russo, Giovanna, additional, and Lo Nigro, Luca, additional
Published: 2016
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Author: Lo Nigro, Luca, primary, Cannata, Emanuela, additional, Samperi, Piera, additional, Munda, Silvana, additional, Bottino, Daria, additional, Mirabile, Elena, additional, Di Cataldo, Andrea, additional, and Russo, Giovanna, additional
Published: 2015
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Author: Nigro, Luca Lo, primary, Sainati, Laura, primary, Leszl, Anna, primary, Mirabile, Elena, primary, Spinelli, Monica, primary, Consarino, Caterina, primary, Di Cataldo, Andrea, primary, Magro, Saverio, primary, Ann Felix, Carolyn, primary, and Basso, Giuseppe, primary
Published: 2005
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Author: Bonaccorso, Paola, La Rosa, Manuela, Andriano, Nellina, Iachelli, Valeria, Cannata, Emanuela, Bellia, Francesco, Licciardello, Marinella, Di Cataldo, Andrea, Russo, Giovanna, and Lo Nigro, Luca
Abstract: Background. Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood and a major cause of childhood cancer-related mortality. Although the cure rate now approaches 90%, certain pediatric ALL subgroups present subsequent relapse. For this reason, analyses of cell signaling pathways will help to identify new markers and/or targets for tailored therapy. PI3K/AKT/mTOR activation is frequently found in both B-ALL and T-ALL. Protein kinase Ck2 (CSNK2) activity in pediatric ALL was increased and its inhibition restored PTEN phosphatase activity with subsequent inactivation of AKT. Moreover, Ck2 may serve the activity of oncogenes such as BCR-ABLand c-MYC, control the activation of other critical signaling cascades (JAK-STAT), and sustain multiple cellular stress-elicited pathway such as the proteotoxic stress, unfolded protein and DNA-damage responses. Ck2 has also been shown to have an essential role in tuning signals derived from the stromal tumor microenvironment (Piazza F et al, Oncogene2016).
Published: 2016
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