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3,574 results on '"Claudio A."'

1. Wiskott-Aldrich syndrome: a study of 577 patients defines the genotype as a biomarker for disease severity and survival

Author

Vallée, Tanja C., Glasmacher, Jannik S., Buchner, Hannes, Arkwright, Peter D., Behrends, Uta, Bondarenko, Anastasia, Browning, Michael J., Buchbinder, David, Cattoni, Alessandro, Chernyshova, Liudmyla, Ciznar, Peter, Cole, Theresa, Czogała, Wojciech, Dueckers, Gregor, Edgar, John David M., Erbey, Fatih, Fasth, Anders, Ferrua, Francesca, Formankova, Renata, Gambineri, Eleonora, Gennery, Andrew R., Goldman, Frederick D., Gonzalez-Granado, Luis I., Heilmann, Carsten, Heiskanen-Kosma, Tarja, Juntti, Hanna, Kainulainen, Leena, Kanegane, Hirokazu, Karaca, Neslihan E., Kilic, Sara S., Klein, Christoph, Kołtan, Sylwia, Kondratenko, Irina, Meyts, Isabelle, Nasrullayeva, Gulnara M., Notarangelo, Lucia D., Pasic, Srdjan, Pellier, Isabelle, Pignata, Claudio, Misbah, Siraj, Schulz, Ansgar, Segundo, Gesmar R., Shcherbina, Anna, Slatter, Mary, Sokolic, Robert, Soler-Palacin, Pere, Stepensky, Polina, van Montfrans, Joris M., Ryhänen, Samppa, Wolska-Kuśnierz, Beata, Ziegler, John B., Zhao, Xiaodong, Aiuti, Alessandro, Ochs, Hans D., and Albert, Michael H.

Published
2024
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2. JAK2/mTOR inhibition fails to prevent acute GVHD despite reduced Th1/Th17 cells: final phase 2 trial results

Author

Pidala, Joseph, Holtan, Shernan G., Walton, Kelly, Kim, Jongphil, Cao, Biwei, Elmariah, Hany, Mishra, Asmita, Bejanyan, Nelli, Nishihori, Taiga, Khimani, Farhad, Perez, Lia, Faramand, Rawan G., Davila, Marco L., McSain, Shannon, Pleskow, Jordan, Baron, Jeffrey, Anasetti, Claudio, Moran Segura, Carlos, Weisdorf, Daniel J., Blazar, Bruce R., Miller, Jeffrey S., Bachanova, Veronika, El Jurdi, Najla, and Betts, Brian C.

Published
2024
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5. Patients' Perception of Usability and Utility of a Digital Health Tool for Electronic Patient-Reported Outcomes Monitoring in Real-Life Hematology Practice: Evidence from the Gimema-Alliance Platform

Author

Efficace, Fabio, primary, Luppi, Mario, additional, Potenza, Leonardo, additional, Sparano, Francesco, additional, Caocci, Giovanni, additional, Fazio, Francesca, additional, Breccia, Massimo, additional, Petrucci, Maria Teresa, additional, Patriarca, Andrea, additional, Baldi, Thomas, additional, Santopietro, Michelina, additional, Battistini, Roberta, additional, Tafuri, Agostino, additional, Margiotta Casaluci, Gloria, additional, Colaci, Elisabetta, additional, Giusti, Davide, additional, Pioli, Valeria, additional, De Fabritiis, Paolo, additional, Ardu, Nicolina Rita, additional, Niscola, Pasquale, additional, Mulas, Olga, additional, Fozza, Claudio, additional, Siragusa, Sergio, additional, Mancuso, Salvatrice, additional, Boggione, Paola, additional, De Paoli, Lorenzo, additional, Leporace, Anna Paola, additional, Bianchi, Maria Paola, additional, Carmosino, Ida, additional, Cartoni, Claudio, additional, Di Rocco, Alice, additional, Capodanno, Isabella, additional, Pini, Massimo, additional, Romano, Alessandra, additional, Fazi, Paola, additional, and Vignetti, Marco, additional

Published
2023
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6. Reproducing the molecular subclassification of peripheral T-cell lymphoma–NOS by immunohistochemistry

Author

Amador, Catalina, Greiner, Timothy C., Heavican, Tayla B., Smith, Lynette M., Galvis, Karen Tatiana, Lone, Waseem, Bouska, Alyssa, D'Amore, Francesco, Pedersen, Martin Bjerregaard, Pileri, Stefano, Agostinelli, Claudio, Feldman, Andrew L., Rosenwald, Andreas, Ott, German, Mottok, Anja, Savage, Kerry J., de Leval, Laurence, Gaulard, Philippe, Lim, Soon Thye, Ong, Choon Kiat, Ondrejka, Sarah L., Song, Joo, Campo, Elias, Jaffe, Elaine S., Staudt, Louis M., Rimsza, Lisa M., Vose, Julie, Weisenburger, Dennis D., Chan, Wing C., and Iqbal, Javeed

Published
2019
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8. R-CHOP preceded by blood-brain barrier permeabilization with engineered tumor necrosis factor-α in primary CNS lymphoma

Author

Ferreri, Andrés J.M., Calimeri, Teresa, Conte, Gian Marco, Cattaneo, Dario, Fallanca, Federico, Ponzoni, Maurilio, Scarano, Eloise, Curnis, Flavio, Nonis, Alessandro, Lopedote, Paolo, Citterio, Giovanni, Politi, Letterio S., Foppoli, Marco, Girlanda, Stefania, Sassone, Marianna, Perrone, Salvatore, Cecchetti, Caterina, Ciceri, Fabio, Bordignon, Claudio, Corti, Angelo, and Anzalone, Nicoletta

Published
2019
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9. Unrelated donor vs HLA-haploidentical α/β T-cell– and B-cell–depleted HSCT in children with acute leukemia

Author

Bertaina, Alice, Zecca, Marco, Buldini, Barbara, Sacchi, Nicoletta, Algeri, Mattia, Saglio, Francesco, Perotti, Cesare, Gallina, Anna Maria, Bertaina, Valentina, Lanino, Edoardo, Prete, Arcangelo, Barberi, Walter, Tumino, Manuela, Favre, Claudio, Cesaro, Simone, Del Bufalo, Francesca, Ripaldi, Mimmo, Boghen, Stella, Casazza, Gabriella, Rabusin, Marco, Balduzzi, Adriana, Fagioli, Franca, Pagliara, Daria, and Locatelli, Franco

Published
2018
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10. Health-Related Quality of Life Profile and Symptom Burden of Patients with Aggressive B-Cell Lymphomas Just before CAR-T-Cell Therapy: A Real-World Study By the Gimema

Author

Efficace, Fabio, primary, Zinzani, Pier Luigi, additional, Bonifazi, Francesca, additional, Clerico, Michele, additional, Chiappella, Annalisa, additional, Russo, Domenico, additional, Saccardi, Riccardo, additional, Botto, Barbara, additional, Baldi, Thomas, additional, Tartaglia, Francesca, additional, Orciuolo, Enrico, additional, Gambella, Massimiliano, additional, Tisi, Maria Chiara, additional, Martelli, Maurizio, additional, Cartoni, Claudio, additional, Di Palma, Martina, additional, Martino, Massimo, additional, Corradini, Paolo, additional, Fazi, Paola, additional, Vignetti, Marco, additional, and Di Rocco, Alice, additional

Published
2023
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11. Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel

Author

de Witte, Theo, Bowen, David, Robin, Marie, Malcovati, Luca, Niederwieser, Dietger, Yakoub-Agha, Ibrahim, Mufti, Ghulam J., Fenaux, Pierre, Sanz, Guillermo, Martino, Rodrigo, Alessandrino, Emilio Paolo, Onida, Francesco, Symeonidis, Argiris, Passweg, Jakob, Kobbe, Guido, Ganser, Arnold, Platzbecker, Uwe, Finke, Jürgen, van Gelder, Michel, van de Loosdrecht, Arjan A., Ljungman, Per, Stauder, Reinhard, Volin, Liisa, Deeg, H.Joachim, Cutler, Corey, Saber, Wael, Champlin, Richard, Giralt, Sergio, Anasetti, Claudio, and Kröger, Nicolaus

Published
2017
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12. Mature CD10+ and immature CD10− neutrophils present in G-CSF–treated donors display opposite effects on T cells

Author

Marini, Olivia, Costa, Sara, Bevilacqua, Dalila, Calzetti, Federica, Tamassia, Nicola, Spina, Cecilia, De Sabata, Donata, Tinazzi, Elisa, Lunardi, Claudio, Scupoli, Maria T., Cavallini, Chiara, Zoratti, Elisa, Tinazzi, Ilaria, Marchetta, Antonio, Vassanelli, Aurora, Cantini, Maurizio, Gandini, Giorgio, Ruzzenente, Andrea, Guglielmi, Alfredo, Missale, Francesco, Vermi, William, Tecchio, Cristina, Cassatella, Marco A., and Scapini, Patrizia

Published
2017
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13. Efficacy and Safety of Luspatercept in Adult Patients with Transfusion-Dependent Anemia Due to Very Low, Low and Intermediate Risk Myelodysplastic Syndromes (MDS) with Ring Sideroblasts, Who Had an Unsatisfactory Response to or Are Ineligible for Erythropoietin-Based Therapy: A Retrospective Multicenter Study By Fondazione Italiana Sindromi Mielodisplastiche (FiSiM ETS)

Author

Luca Lanino, Prassede Salutari, Alessandra Perego, Bruno Fattizzo, Marta Riva, Marta Ubezio, Pellegrino Musto, Daniela Cilloni, Esther Natalie Oliva, Maria Teresa Voso, Anna Maria Pelizzari, Antonella Poloni, Isabella Capodanno, Chiara Elena, Claudio Fozza, Fabrizio Pane, Massimo Breccia, Marco De Gobbi, Francesco Di Bassiano, Daniela Barraco, Elena Crisà, Dario Ferrero, Chiara Frairia, Antonella Vaccarino, Davide Griguolo, Stefania Paolini, Martina Quintini, Mariarosaria Sessa, Mauro Turrini, Monica Bocchia, Nicola Di Renzo, Elisa Diral, Cristina Foli, Alfredo Molteni, Ubaldo Occhini, Giulia Rivoli, Carmine Selleri, Roberto Bono, Anna Calvisi, Andrea Castelli, Eros Di Bona, Ambra Di Veroli, Luana Fianchi, Sara Galimberti, Daniele Grimaldi, Monia Marchetti, Marianna Norata, Alessandro Rambaldi, Ilaria Tanasi, Patrizia Tosi, Ilaria Naldi, Valeria Santini, and Matteo G. Della Porta

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

14. Molecular Characterization of Clinical Response and Relapse in Patients with IDH1m ND-AML Treated with Ivo+AZA in the AGILE Study

Author

Hartmut Döhner, Dylan M. Marchione, Sung Choe, Pau Montesinos, Christian Recher, Susana Vives, Ewa Zarzycka, Jianxiang Wang, Claudio Cerchione, Michael Heuser, Rodrigo T. Calado, Andre C. Schuh, Su-Peng Yeh, Adolfo De La Fuente, Jianan Hui, Prapti Patel, Diego A. Gianolio, Scott R. Daigle, Courtney D. DiNardo, and Stephane De Botton

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

15. Gene expression–based discovery of atovaquone as a STAT3 inhibitor and anticancer agent

Author

Xiang, Michael, Kim, Haesook, Ho, Vincent T., Walker, Sarah R., Bar-Natan, Michal, Anahtar, Melodi, Liu, Suhu, Toniolo, Patricia A., Kroll, Yasmin, Jones, Nichole, Giaccone, Zachary T., Heppler, Lisa N., Ye, Darwin Q., Marineau, Jason J., Shaw, Daniel, Bradner, James E., Blonquist, Traci, Neuberg, Donna, Hetz, Claudio, Stone, Richard M., Soiffer, Robert J., and Frank, David A.

Published
2016
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17. The effect of donor characteristics on survival after unrelated donor transplantation for hematologic malignancy

Author

Kollman, Craig, Spellman, Stephen R., Zhang, Mei-Jie, Hassebroek, Anna, Anasetti, Claudio, Antin, Joseph H., Champlin, Richard E., Confer, Dennis L., DiPersio, John F., Fernandez-Viña, Marcelo, Hartzman, Robert J., Horowitz, Mary M., Hurley, Carolyn K., Karanes, Chatchada, Maiers, Martin, Mueller, Carlheinz R., Perales, Miguel-Angel, Setterholm, Michelle, Woolfrey, Ann E., Yu, Neng, and Eapen, Mary

Published
2016
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18. CD84: A Novel Target for CAR T-Cell Therapy for Acute Myeloid Leukemia

Author

Lorena Pérez-Amill, Mercedes Armand-Ugon, Sergio Peña, Maria Val Casals, Claudio Santos, Gerard Frigola, Alfredo Minguela, Àlex Bataller Torralba, Berta Casanovas, José Álamo, Mireia Uribe, Diego Sánchez-Martínez, Néstor Tirado, Clara Bueno, Paola Alejandra Romecín, Pablo Menéndez, Antonio Martínez, Montserrat Rovira, Jordi Esteve, Álvaro Urbano-Ispizua, Julio Delgado, Manel Juan, and Nela Klein-González

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

19. The LSC17 Score Correlates with the ELN 2022 Classification of AML and Is an Independent Predictor of Detectable Measurable Residual Disease after Induction Chemotherapy

Author

Tracy Murphy, Stanley W.K. Ng, Ian King, Tong Zhang, Andrea Arruda, Jaime Claudio, Kristele Pan, Chantal Rockwell, Zhibin Lu, Natalie Stickle, Carl Virtanen, Vikas Gupta, Dawn Maze, Caroline McNamara, Aaron D. Schimmer, Andre C. Schuh, Hassan Sibai, Karen Yee, Dina Khalaf, Brian Leber, Mitchell Sabloff, Anne Tierens, Mark D. Minden, Tracy L. Stockley, Steven Chan, and Jean C.Y. Wang

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

20. Health-Related Quality of Life of Patients with Philadelphia-Negative Myeloproliferative Neoplasms Compared with the General Population: A Preliminary Report from the Gimema Prophecy Study

Author

Giovanni Caocci, Francesca Palandri, Giuseppe Gaetano Loscocco, Alfonso Piciocchi, Alessandra Iurlo, Alessia Tieghi, Andrea Patriarca, Elisabetta Abruzzese, Simona Tomassetti, Monia Marchetti, Daniele Vanni, Mario Luppi, Fabrizio Pane, Massimo Breccia, Sergio Siragusa, Elena Maria Elli, Alessandra Ricco, Claudio Fozza, Maria Teresa Corsetti, Carmen Fava, Camilla Mazzoni, Paola Fazi, Giorgio La Nasa, Marco Vignetti, Alessandro M. Vannucchi, and Fabio Efficace

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

21. Alnuctamab (ALNUC; BMS-986349; CC-93269), a B-Cell Maturation Antigen (BCMA) x CD3 T-Cell Engager (TCE), in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Results from a Phase 1 First-in-Human Clinical Study

Author

Sandy W. Wong, Noffar Bar, Laura Paris, Craig C Hofmeister, Markus Hansson, Armando Santoro, Maria-Victoria Mateos, Paula Rodríguez-Otero, Johan Lund, Cristina Encinas, Andrew J. Yee, Albert Oriol, Claudio Cerchione, Javier de la Rubia, Barbara Ferstl, Kristina Carlson, Paz Ribas, Arancha Bermúdez, Isaac W. Boss, Allison Gaudy, Shaoyi Li, Kevin Hsu, Colin D. Godwin, Michael R. Burgess, Jesús San-Miguel, and Luciano J. Costa

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

22. Phase I Trial of CD8-Depleted Human Leukocyte Antigen (HLA) Mismatched Unrelated Donor Lymphocyte Infusion (DLI) to Achieve Remissions in Myelodysplastic Syndrome (MDS) and Secondary Acute Myeloid Leukemia (sAML)

Author

Hany Elmariah, Jongphil Kim, Kayla M. Reid, Christopher Cubitt, Andrew Kuykendall, Jeffrey E. Lancet, Rami S. Komrokji, David A. Sallman, Onyee Chan, Kendra Sweet, Albert J Ribickas, Rawan Faramand, Asmita Mishra, Farhad Khimani, Lia Perez, Debra Kessler, Stephanie Dormesy, Joseph Pidala, Claudio Anasetti, Ephraim J. Fuchs, Michael D. Jain, Frederick L. Locke, Marco L. Davila, Nelli Bejanyan, and Amy E. DeZern

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

23. Bone Marrow-Free Sequencing of M Protein Genes in Monoclonal Gammopathies

Author

Alice Nevone, Giulia Mazzini, Paolo Milani, Silvia Mangiacavalli, Anna Melati, Giulia Scanavino, Maria Girelli, Serena Caminito, Marco Basset, Claudio Salvatore Cartia, Pietro Benvenuti, Martina Nanci, Claudia Bellofiore, Andrea Foli, Giampaolo Merlini, Luca Arcaini, Giovanni Palladini, and Mario Nuvolone

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

24. Impact of Obesity and Weight-Based Chemotherapy Dosing Adjustments on Outcomes of Allogeneic Hematopoietic Cell Transplant Outcomes for Acute Myeloid Leukemia

Author

Omar Albanyan, Syeda Mahrukh Hussnain Naqvi, Qianxing Mo, Athena Belfon, Eric Gaskill, Taiga Nishihori, Rawan Faramand, Aleksandr Lazaryan, Doris K. Hansen, Farhad Khimani, Asmita Mishra, Michael Nieder, Lia Perez, Hien D. Liu, Joseph Pidala, Claudio Anasetti, Frederick L. Locke, Nelli Bejanyan, and Hany Elmariah

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

25. Prospective and Retrospective Observational Study in Adult and Pediatric Patients with GATA2 Variants (GATA2 Deficiency)

Author

Samuele Roncareggi, Katia Girardi, Francesca Fioredda, Francesca Conti, Erika Borlenghi, Concetta Micalizzi, Gaia Mancuso, Fabiola Guerra, Emilia Cirillo, Antonio Marzollo, Piero Farruggia, Daniela Onofrillo, Riccardo Masetti, Raffaele Badolato, Luca Arcuri, Tiziana Angela Coliva, Francesca Vendemini, Claudio Pignata, Sonia Bonanomi, Andrea Biondi, and Francesco Saettini

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

26. Sirolimus Results in Similar Outcomes to Tacrolimus for Gvhd Prophylaxis after Haploidentical Peripheral Blood Stem Cell Transplantation with Post-Transplant Cyclophosphamide

Author

Hany Elmariah, Salman Otoukesh, Ambuj Kumar, Haris Ali, Shukaib Arslan, Amrita Desai, Amanda Blackmon, Hoda Pourhassan, Taiga Nishihori, Rawan Faramand, Asmita Mishra, Farhad Khimani, Hugo F Fernandez, Aleksandr Lazaryan, Michael Nieder, Lia Perez, Hien D. Liu, Ryotaro Nakamura, Joseph Pidala, Guido Marcucci, Stephen J Forman, Claudio Anasetti, Frederick L. Locke, Nelli Bejanyan, and Monzr M. Al Malki

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

29. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

Author

Alinari, Lapo, Mahasenan, Kiran V., Yan, Fengting, Karkhanis, Vrajesh, Chung, Ji-Hyun, Smith, Emily M., Quinion, Carl, Smith, Porsha L., Kim, Lisa, Patton, John T., Lapalombella, Rosa, Yu, Bo, Wu, Yun, Roy, Satavisha, De Leo, Alessandra, Pileri, Stefano, Agostinelli, Claudio, Ayers, Leona, Bradner, James E., Chen-Kiang, Selina, Elemento, Olivier, Motiwala, Tasneem, Majumder, Sarmila, Byrd, John C., Jacob, Samson, Sif, Said, Li, Chenglong, and Baiocchi, Robert A.

Published
2015
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32. Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy

Author

Ethan McClain, Sweta Desai, Amanda F. Cashen, Mark P. Foster, Peter Westervelt, Patrick Soon-Shiong, Michelle Becker-Hapak, Keith Stockerl-Goldstein, Jeffrey S. Miller, Miriam T. Jacobs, Mark A. Schroeder, Pamela Wong, Camille N. Abboud, Patrick Pence, Geoffrey L. Uy, Feng Gao, Claudio G. Brunstein, Melissa M. Berrien-Elliott, Meagan A. Jacoby, Iskra Pusic, Sarah Cooley, John F. DiPersio, and Todd A. Fehniger

Subjects
Male, Adoptive cell transfer, Recombinant Fusion Proteins, T cell, Lymphocyte, Immunology, Antineoplastic Agents, CD8-Positive T-Lymphocytes, Immunotherapy, Adoptive, Biochemistry, Natural killer cell, Cell therapy, Humans, Medicine, Cytotoxic T cell, Interleukin-15, business.industry, Allogeneic Cells, Hematopoietic Stem Cell Transplantation, Cell Biology, Hematology, Killer Cells, Natural, Leukemia, Myeloid, Acute, medicine.anatomical_structure, Interleukin 15, Cancer research, Female, business, CD8
Abstract

Natural killer (NK) cells are a promising alternative to T cells for cancer immunotherapy. Adoptive therapies with allogeneic, cytokine-activated NK cells are being investigated in clinical trials. However, the optimal cytokine support after adoptive transfer to promote NK cell expansion, and persistence remains unclear. Correlative studies from 2 independent clinical trial cohorts treated with major histocompatibility complex-haploidentical NK cell therapy for relapsed/refractory acute myeloid leukemia revealed that cytokine support by systemic interleukin-15 (IL-15; N-803) resulted in reduced clinical activity, compared with IL-2. We hypothesized that the mechanism responsible was IL-15/N-803 promoting recipient CD8 T-cell activation that in turn accelerated donor NK cell rejection. This idea was supported by increased proliferating CD8+ T-cell numbers in patients treated with IL-15/N-803, compared with IL-2. Moreover, mixed lymphocyte reactions showed that IL-15/N-803 enhanced responder CD8 T-cell activation and proliferation, compared with IL-2 alone. Additionally, IL-15/N-803 accelerated the ability of responding T cells to kill stimulator-derived memory-like NK cells, demonstrating that additional IL-15 can hasten donor NK cell elimination. Thus, systemic IL-15 used to support allogeneic cell therapy may paradoxically limit their therapeutic window of opportunity and clinical activity. This study indicates that stimulating patient CD8 T-cell allo-rejection responses may critically limit allogeneic cellular therapy supported with IL-15. This trial was registered at www.clinicaltrials.gov as #NCT03050216 and #NCT01898793.

Published
2022

33. Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypes

Author

Piccaluga, Pier Paolo, De Falco, Giulia, Kustagi, Manjunath, Gazzola, Anna, Agostinelli, Claudio, Tripodo, Claudio, Leucci, Eleonora, Onnis, Anna, Astolfi, Annalisa, Sapienza, Maria Rosaria, Bellan, Cristiana, Lazzi, Stefano, Tumwine, Lynnette, Mawanda, Michael, Ogwang, Martin, Calbi, Valeria, Formica, Serena, Califano, Andrea, Pileri, Stefano A., and Leoncini, Lorenzo

Published
2011
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34. Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome

Author

Rinaldi, Andrea, Mian, Michael, Chigrinova, Ekaterina, Arcaini, Luca, Bhagat, Govind, Novak, Urban, Rancoita, Paola M.V., De Campos, Cassio P., Forconi, Francesco, Gascoyne, Randy D., Facchetti, Fabio, Ponzoni, Maurilio, Govi, Silvia, Ferreri, Andrés J.M., Mollejo, Manuela, Piris, Miguel A., Baldini, Luca, Soulier, Jean, Thieblemont, Catherine, Canzonieri, Vincenzo, Gattei, Valter, Marasca, Roberto, Franceschetti, Silvia, Gaidano, Gianluca, Tucci, Alessandra, Uccella, Silvia, Tibiletti, Maria Grazia, Dirnhofer, Stephan, Tripodo, Claudio, Doglioni, Claudio, Dalla Favera, Riccardo, Cavalli, Franco, Zucca, Emanuele, Kwee, Ivo, and Bertoni, Francesco

Published
2011
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35. Cereblon enhancer methylation and IMiD resistance in multiple myeloma

Author

Thorsten Stühmer, Cornelia Vogt, Manik Chatterjee, Rafael Alonso Fernández, José I. Martín-Subero, K. Martin Kortüm, Peter Raab, Seungbin Han, Larissa Haertle, Yanira Ruiz-Heredia, Umair Munawar, Jan Krönke, Miriam Kull, Leo Rasche, Xiang Zhou, Hermann Einsele, Xabier Agirre, Niccolo Bolli, Anna Ruckdeschel, Josip Zovko, Joaquin Martinez-Lopez, Andoni Garitano-Trojaola, Matteo Claudio Da Via, Max Bittrich, Thomas Haaf, and Santiago Barrio

Subjects
Ubiquitin-Protein Ligases, Immunology, DNA Methyltransferase Inhibitor, Drug resistance, Biochemistry, Immunomodulating Agents, Antineoplastic Agents, Immunological, medicine, Humans, Enhancer, Multiple myeloma, Adaptor Proteins, Signal Transducing, Lenalidomide, Lymphoid Neoplasia, Chemistry, Cereblon, Cell Biology, Hematology, Methylation, DNA Methylation, medicine.disease, Introns, Enhancer Elements, Genetic, Drug Resistance, Neoplasm, DNA methylation, Cancer research, Multiple Myeloma, medicine.drug
Abstract

Cereblon is the direct binding target of the immunomodulatory drugs (IMiDs) that are commonly used to treat multiple myeloma (MM), the second most frequent hematologic malignancy. Patients respond well to initial treatment with IMiDs, but virtually all patients develop drug resistance over time, and the underlying mechanisms are poorly understood. We identified an as yet undescribed DNA hypermethylation in an active intronic CRBN enhancer. Differential hypermethylation in this region was found to be increased in healthy plasma cells, but was more pronounced in IMiD-refractory MM. Methylation significantly correlated with decreased CRBN expression levels. DNA methyltransferase inhibitor (DNTMi) in vitro experiments induced CRBN enhancer demethylation, and sensitizing effects on lenalidomide treatment were observed in 2 MM cell lines. Thus, we provide first evidence that aberrant CRBN DNA methylation is a novel mechanism of IMiD resistance in MM and may predict IMiD response prior to treatment.

Published
2021

38. Acute Myeloid Leukemia (AML) Risk Stratification Using the European Leukemianet 2022 Classification in a Real-Life Cohort of Patients from Sardinia, Italy

Author

Piras, Giovanna, primary, Uras, Antonella, additional, Cucca, Antonella, additional, Monne, Maria, additional, Costa, Alessandro, additional, Chiriu, Sabrina, additional, Longu, Francesco, additional, Murineddu, Marco, additional, Arru, Luigi Benedetto, additional, Bianchi, Alessandro, additional, Calvisi, Anna, additional, Di Francesco, Alessandra, additional, Murgia, Alessandro, additional, Cambosu, Francesca, additional, Flagiello, Mauro P, additional, Isoni, Maria Antonia, additional, Caocci, Giovanni, additional, Fozza, Claudio, additional, and Palmas, Angelo D., additional

Published
2022
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39. Real-Life Outcome of Patients with Newly Diagnosed Symptomatic Multiple Myeloma Treated with VTD Induction Followed By Single or Double ASCT: A Retrospective Analysis from a Single Institution

Author

Serpenti, Fabio, primary, Shankar, Anushka, additional, Rampi, Nicolo', additional, Mocellin, Cristina, additional, Fidanza, Cecilia, additional, Goldaniga, Maria Cecilia, additional, Saporiti, Giorgia, additional, Da Via, Matteo Claudio, additional, Galassi, Giulia, additional, Pettine, Loredana, additional, Bagnoli, Filippo, additional, Bolli, Niccolo, additional, Baldini, Luca, additional, Pompa, Alessandra, additional, and Onida, Francesco, additional

Published
2022
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40. Efficacy and Safety of Luspatercept in Adult Patients with Transfusion-Dependent Anemia Due to Very Low, Low and Intermediate Risk Myelodysplastic Syndromes (MDS) with Ring Sideroblasts, Who Had an Unsatisfactory Response to or Are Ineligible for Erythropoietin-Based Therapy: A Retrospective Multicenter Study By Fondazione Italiana Sindromi Mielodisplastiche (FiSiM ETS)

Author

Lanino, Luca, primary, Salutari, Prassede, additional, Perego, Alessandra, additional, Fattizzo, Bruno, additional, Riva, Marta, additional, Ubezio, Marta, additional, Musto, Pellegrino, additional, Cilloni, Daniela, additional, Oliva, Esther Natalie, additional, Voso, Maria Teresa, additional, Pelizzari, Anna Maria, additional, Poloni, Antonella, additional, Capodanno, Isabella, additional, Elena, Chiara, additional, Fozza, Claudio, additional, Pane, Fabrizio, additional, Breccia, Massimo, additional, De Gobbi, Marco, additional, Di Bassiano, Francesco, additional, Barraco, Daniela, additional, Crisà, Elena, additional, Ferrero, Dario, additional, Frairia, Chiara, additional, Vaccarino, Antonella, additional, Griguolo, Davide, additional, Paolini, Stefania, additional, Quintini, Martina, additional, Sessa, Mariarosaria, additional, Turrini, Mauro, additional, Bocchia, Monica, additional, Di Renzo, Nicola, additional, Diral, Elisa, additional, Foli, Cristina, additional, Molteni, Alfredo, additional, Occhini, Ubaldo, additional, Rivoli, Giulia, additional, Selleri, Carmine, additional, Bono, Roberto, additional, Calvisi, Anna, additional, Castelli, Andrea, additional, Di Bona, Eros, additional, Di Veroli, Ambra, additional, Fianchi, Luana, additional, Galimberti, Sara, additional, Grimaldi, Daniele, additional, Marchetti, Monia, additional, Norata, Marianna, additional, Rambaldi, Alessandro, additional, Tanasi, Ilaria, additional, Tosi, Patrizia, additional, Naldi, Ilaria, additional, Santini, Valeria, additional, and Della Porta, Matteo G., additional

Published
2022
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41. Impact of Obesity and Weight-Based Chemotherapy Dosing Adjustments on Outcomes of Allogeneic Hematopoietic Cell Transplant Outcomes for Acute Myeloid Leukemia

Author

Albanyan, Omar, primary, Naqvi, Syeda Mahrukh Hussnain, additional, Mo, Qianxing, additional, Belfon, Athena, additional, Gaskill, Eric, additional, Nishihori, Taiga, additional, Faramand, Rawan, additional, Lazaryan, Aleksandr, additional, Hansen, Doris K., additional, Khimani, Farhad, additional, Mishra, Asmita, additional, Nieder, Michael, additional, Perez, Lia, additional, Liu, Hien D., additional, Pidala, Joseph, additional, Anasetti, Claudio, additional, Locke, Frederick L., additional, Bejanyan, Nelli, additional, and Elmariah, Hany, additional

Published
2022
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42. Alnuctamab (ALNUC; BMS-986349; CC-93269), a B-Cell Maturation Antigen (BCMA) x CD3 T-Cell Engager (TCE), in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Results from a Phase 1 First-in-Human Clinical Study

Author

Wong, Sandy W., primary, Bar, Noffar, additional, Paris, Laura, additional, Hofmeister, Craig C, additional, Hansson, Markus, additional, Santoro, Armando, additional, Mateos, Maria-Victoria, additional, Rodríguez-Otero, Paula, additional, Lund, Johan, additional, Encinas, Cristina, additional, Yee, Andrew J., additional, Oriol, Albert, additional, Cerchione, Claudio, additional, de la Rubia, Javier, additional, Ferstl, Barbara, additional, Carlson, Kristina, additional, Ribas, Paz, additional, Bermúdez, Arancha, additional, Boss, Isaac W., additional, Gaudy, Allison, additional, Li, Shaoyi, additional, Hsu, Kevin, additional, Godwin, Colin D., additional, Burgess, Michael R., additional, San-Miguel, Jesús, additional, and Costa, Luciano J., additional

Published
2022
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44. Dysregulation of PRMT5 in Chronic Lymphocytic Leukemia Supports Transformation to Diffuse Large B-Cell Lymphoma

Author

Whipp, Ethan, primary, Hing, Zachary A, additional, Walker, Janek S., additional, Sher, Steven, additional, Cempre, Casey B., additional, Brown, Fiona, additional, Agostinelli, Claudio, additional, Pileri, Stefano A, additional, Williams, Katie, additional, Beaver, Larry, additional, Pan, Alexander, additional, Gregory, Charles T., additional, Yan, Pearlly S., additional, Scherle, Peggy, additional, Wang, Min, additional, Vaddi, Kris, additional, Chen-Kiang, Selina, additional, Woyach, Jennifer A., additional, Blachly, James S., additional, Alinari, Lapo, additional, Yang, Yiping, additional, Baiocchi, Robert A., additional, Blaser, Bradley W, additional, and Lapalombella, Rosa, additional

Published
2022
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46. Sirolimus Results in Similar Outcomes to Tacrolimus for Gvhd Prophylaxis after Haploidentical Peripheral Blood Stem Cell Transplantation with Post-Transplant Cyclophosphamide

Author

Elmariah, Hany, primary, Otoukesh, Salman, additional, Kumar, Ambuj, additional, Ali, Haris, additional, Arslan, Shukaib, additional, Desai, Amrita, additional, Blackmon, Amanda, additional, Pourhassan, Hoda, additional, Nishihori, Taiga, additional, Faramand, Rawan, additional, Mishra, Asmita, additional, Khimani, Farhad, additional, Fernandez, Hugo F, additional, Lazaryan, Aleksandr, additional, Nieder, Michael, additional, Perez, Lia, additional, Liu, Hien D., additional, Nakamura, Ryotaro, additional, Pidala, Joseph, additional, Marcucci, Guido, additional, Forman, Stephen J, additional, Anasetti, Claudio, additional, Locke, Frederick L., additional, Bejanyan, Nelli, additional, and Al Malki, Monzr M., additional

Published
2022
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48. Phase I Trial of CD8-Depleted Human Leukocyte Antigen (HLA) Mismatched Unrelated Donor Lymphocyte Infusion (DLI) to Achieve Remissions in Myelodysplastic Syndrome (MDS) and Secondary Acute Myeloid Leukemia (sAML)

Author

Elmariah, Hany, primary, Kim, Jongphil, additional, Reid, Kayla M., additional, Cubitt, Christopher, additional, Kuykendall, Andrew, additional, Lancet, Jeffrey E., additional, Komrokji, Rami S., additional, Sallman, David A., additional, Chan, Onyee, additional, Sweet, Kendra, additional, Ribickas, Albert J, additional, Faramand, Rawan, additional, Mishra, Asmita, additional, Khimani, Farhad, additional, Perez, Lia, additional, Kessler, Debra, additional, Dormesy, Stephanie, additional, Pidala, Joseph, additional, Anasetti, Claudio, additional, Fuchs, Ephraim J., additional, Jain, Michael D., additional, Locke, Frederick L., additional, Davila, Marco L., additional, Bejanyan, Nelli, additional, and DeZern, Amy E., additional

Published
2022
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50. Prospective and Retrospective Observational Study in Adult and Pediatric Patients with GATA2 Variants (GATA2 Deficiency)

Author

Roncareggi, Samuele, primary, Girardi, Katia, additional, Fioredda, Francesca, additional, Conti, Francesca, additional, Borlenghi, Erika, additional, Micalizzi, Concetta, additional, Mancuso, Gaia, additional, Guerra, Fabiola, additional, Cirillo, Emilia, additional, Marzollo, Antonio, additional, Farruggia, Piero, additional, Onofrillo, Daniela, additional, Masetti, Riccardo, additional, Badolato, Raffaele, additional, Arcuri, Luca, additional, Coliva, Tiziana Angela, additional, Vendemini, Francesca, additional, Pignata, Claudio, additional, Bonanomi, Sonia, additional, Biondi, Andrea, additional, and Saettini, Francesco, additional

Published
2022
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