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Your search keyword '"Chinnaswamy, Krishnapriya"' showing total 4 results
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4 results on '"Chinnaswamy, Krishnapriya"'

1. Novel Chemical Series of Anti-ST2 Small Molecules Suppress Allogeneic T Cells Proliferation While Increasing Treg Cells and Improve Gvhd and Survival In Vivo

Author

Yang, Chao-Yie, primary, Yuan, Xinrui, additional, Jiang, Hua, additional, Rech, Jason C., additional, Fu, Denggang, additional, Robida, Aaron, additional, Rajanayake, Krishani, additional, Yuan, Hebao, additional, Wen, Bo, additional, Sun, Duxin, additional, Chinnaswamy, Krishnapriya, additional, Stuckey, Jeanne A., additional, and Paczesny, Sophie, additional

Published
2022
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4. Small-Molecule U2 Auxiliary Factor Homology Motif (UHM) Domain Inhibitors Cause Splicing Pattern Changes in U2AF1Mutant Leukemia Cells and Induce Sub-G1 Cell Cycle Arrest

Author

Yang, Chao-Yie, Yuan, Xinrui, Kazemi Sabzvar, Mona, Durmaz, Arda, Chinnaswamy, Krishnapriya, Stuckey, Jeanne, Corey, Seth J, Maciejewski, Jaroslaw P., and Visconte, Valeria

Abstract

Mutations in factors involved in the spliceosomal pathway have emerged to be an important contributor to the development of myeloid neoplasms including MDS and secondary AML (sAML). A set of frequently mutated genes encoding RNA splicing factors including SF3B1, U2AF1, SRSF2, and ZRSR2or haploinsufficiency of LUC7L2have beenreported, but pharmacological intervention targeting these genes remains limited and under-developed. Combination of mutations of these splicing factors are rarely found in patients indicating that multiple defects in a spliceosome pathway may be deleterious. Heterozygous mutation in U2AF1found in MDS leads to the acquisition of the neomorphic mutant U2AF1 (U2AF1 wt) that relies on wild-type U2AF1 (U2AF1 wt) to survive and proliferate.

Published
2023
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