148 results on '"CHEN, CHUN"'
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2. PLCG1 is required for AML1-ETO leukemia stem cell self-renewal
3. Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition
4. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia
5. PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia
6. Screening of Differential DNA Methylation Sites and Signal Pathway Analysis of Juvenile Myelomonocytic Leukemia in Children before and after Decitabine Treatment
7. Niclosamide Inhibits the Growth of Acute Lymphoblastic Leukemia Cells By Increasing Intracellular ROS and Activation of p53-PUMA/NOXA
8. Aurora Kinase B/C Inhibitor GSK1070916 Specifically Targets Juvenile Myelomonocytic Leukemia Cells with SHP2(PTPN11) Mutation
9. Mutant NPM1 Is Recruited to MLL Target Genes Via Its Acidic Stretch and Nuclear Export Factor CRM1 and Regulates Oncogenic Transcription in Acute Myeloid Leukemia
10. TP63 Fusions Drive Enhancer Rewiring, Lymphomagenesis, and Dependence on EZH2
11. The Menin Inhibitor Ziftomenib (KO-539) Synergizes with Agents Targeting Chromatin Regulation or Apoptosis and Sensitizes AML with MLL Rearrangement or NPM1 Mutation to Venetoclax
12. Establishment of Stable Cell Lines Representing Juvenile Myelomonocytic Leukemia with SHP2 Mutations
13. Small Molecule Kinase Inhibitor Sunitinib Specifically Targets Juvenile Myelomonocytic Leukemia Cells with SHP2(PTPN11) Mutation
14. Small Molecule Inhibition of PDE6D-RAS Interaction Suppresses the Growth of Acute Lymphoblastic Leukemia Cell Lines
15. Insufficient Phosphorylation of STAT5 in Tregs Inhibits the Expression of BLIMP-1, Leading to a Lack of Tregs in Pediatric Aplastic Anemia
16. Distinctive localization of antigen-presenting cells in human lymph nodes
17. The biologic properties of leukemias arising from BCR/ABL-mediated transformation vary as a function of developmental origin and activity of the p19ARF gene
18. FLT3 Ligand-DM1 Conjugate Selectively Targets Acute Myeloid Leukemia Cells with FLT3 Expression
19. Tumor Associated Macrophages Express High-Levels of FLT3 Ligand, Which Induces Activation of FLT3 Signaling That Promotes Survival of Neoplastic Cells in B-Cell Acute Lymphoblastic Leukemia
20. Identification of ZNF217 As an Essential Oncogenic Gene in B-Cell Acute Lymphoblastic Leukemia By CRISPR/Cas9-Based Library Screening
21. Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis
22. Tudor Domain-Focused CRISPR Dropout Screen Identifies SGF29 As a Novel Essential Gene in MLL-Rearranged Leukemias
23. Clinical Outcome of Pediatric Acquired Aplastic Anemia Underwent Immunosuppressive Therapy and Transplantation: A 13-Year Experience in Two Tertiary Care Centers , Southern China
24. Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling
25. Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism
26. HDAC8 Promotes MLL-Rearranged Acute Myeloid Leukemia By Inhibiting p53 Acetylation
27. Identification of a Novel Indel Mutation in GATA-1 Gene In Vivo and Verified Its Defective Function in Vitro
28. Combined Targeting of the Menin-MLL1 Chromatin Complex and FLT3 As a Novel Therapeutic Concept Against NPM1 Mutant or MLL-Rearranged AML with Mutated FLT3
29. Inhibition of PRMT1 Mediated FLT3 Arginine Methylation As a Potent Therapeutic Strategy for MLL-r ALL
30. High-Density CRISPR Scan Identifies Functional Regions of DOT1L That Mediate Therapeutic Response in MLL-r Leukemia
31. CD25-Dependent Feedback Control of the B-Cell Receptor and Its Oncogenic Mimics in B-Cell Malignancies
32. Synergistic targeting of FLT3mutations in AML via combined menin-MLL and FLT3 inhibition
33. Non-Catalytic Role of SETD1A Regulates DNA Repair in Leukemia
34. An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL-Rearranged Leukemia to DOT1L Inhibition
35. COX4I1 Controls Mitochondrial Electron Transport Chain Complex IV Assembly and Leukemia Progression in Acute Myeloid Leukemia
36. The Kinetics of FLT3L during Induction Chemotherapy for Pediatric Acute Lymphoblastic Leukemia Suggests a Novel Clinical Diagnostic and Treatment Strategy
37. Inherent Genome Instability Underlies Trisomy 21-Associated Myeloid Malignancies
38. PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+acute myeloid leukemia
39. Genome-Wide RNAi Screen Identifies The Mechanistic Role For DOT1L In MLL-Rearranged Leukemia
40. Myeloid Leukemia Cells With MLL partial Tandem Duplication Are Sensitive To Pharmacological Inhibition Of The H3K79 Methyltransferase DOT1L
41. siRNA Mediated Knockdown of the Chimeric Transcription Factor E2A-PBX1 Identifies Potential Target Genes.
42. The Presence and Number of Activatory KIR (R+D−) Impact the Infection and Survival Status of Patients Transplanted with an HLA Matched Sibling Donor.
43. Pre-Clinical Trial on the Co-Transplantation of MSCs and Umbilical Cord Blood Stem Cells
44. Higher Frequency of Glutathione S-Transferase Deletions in Black Children With Acute Lymphoblastic Leukemia
45. Etoposide Causes Illegitimate V(D)J Recombination in Human Lymphoid Leukemic Cells
46. Ifitm3Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis
47. Identification of a Novel Indel Mutation in GATA-1Gene In Vivo and Verified Its Defective Function in Vitro
48. Tudor Domain-Focused CRISPR Dropout Screen Identifies SGF29As a Novel Essential Gene in MLL-Rearranged Leukemias
49. Combined Targeting of the Menin-MLL1 Chromatin Complex and FLT3 As a Novel Therapeutic Concept Against NPM1Mutant or MLL-Rearranged AML with Mutated FLT3
50. A Multicenter Nonrandom Clinical Study of Induction Regimen of FLAG-ID and Dae in the Treatment of Childhood De Novo Acute Myeloid Leukemia in South of China:the Early Report of Efficacy and Safety
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