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Your search keyword '"Bracci, Paige M."' showing total 13 results
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13 results on '"Bracci, Paige M."'

1. Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis

Author

Kleinstern, Geffen, Camp, Nicola J., Goldin, Lynn R., Vachon, Celine M., Vajdic, Claire M., de Sanjose, Silvia, Weinberg, J. Brice, Benavente, Yolanda, Casabonne, Delphine, Liebow, Mark, Nieters, Alexandra, Hjalgrim, Henrik, Melbye, Mads, Glimelius, Bengt, Adami, Hans-Olov, Boffetta, Paolo, Brennan, Paul, Maynadie, Marc, McKay, James, Cocco, Pier Luigi, Shanafelt, Tait D., Call, Timothy G., Norman, Aaron D., Hanson, Curtis, Robinson, Dennis, Chaffee, Kari G., Brooks-Wilson, Angela R., Monnereau, Alain, Clavel, Jacqueline, Glenn, Martha, Curtin, Karen, Conde, Lucia, Bracci, Paige M., Morton, Lindsay M., Cozen, Wendy, Severson, Richard K., Chanock, Stephen J., Spinelli, John J., Johnston, James B., Rothman, Nathaniel, Skibola, Christine F., Leis, Jose F., Kay, Neil E., Smedby, Karin E., Berndt, Sonja I., Cerhan, James R., Caporaso, Neil, and Slager, Susan L.

Published
2018
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3. PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium

Author

Nieters, Alexandra, Conde, Lucia, Slager, Susan L., Brooks-Wilson, Angela, Morton, Lindsay, Skibola, Danica R., Novak, Anne J., Riby, Jacques, Ansell, Stephen M., Halperin, Eran, Shanafelt, Tait D., Agana, Luz, Wang, Alice H., De Roos, Anneclaire J., Severson, Richard K., Cozen, Wendy, Spinelli, John, Butterbach, Katja, Becker, Nikolaus, de Sanjose, Silvia, Benavente, Yolanda, Cocco, Pierluigi, Staines, Anthony, Maynadié, Marc, Foretova, Lenka, Boffetta, Paolo, Brennan, Paul, Lan, Qing, Zhang, Yawei, Zheng, Tongzhang, Purdue, Mark, Armstrong, Bruce, Kricker, Anne, Vajdic, Claire M., Grulich, Andrew, Smith, Martyn T., Bracci, Paige M., Chanock, Stephen J., Hartge, Patricia, Cerhan, James R., Wang, Sophia S., Rothman, Nathaniel, and Skibola, Christine F.

Published
2012
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4. Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia

Author

Slager, Susan L., Skibola, Christine F., Di Bernardo, Maria Chiara, Conde, Lucia, Broderick, Peter, McDonnell, Shannon K., Goldin, Lynn R., Croft, Naomi, Holroyd, Amy, Harris, Shelley, Riby, Jacques, Serie, Daniel J., Kay, Neil E., Call, Timothy G., Bracci, Paige M., Halperin, Eran, Lanasa, Mark C., Cunningham, Julie M., Leis, Jose F., Morrison, Vicki A., Spector, Logan G., Vachon, Celine M., Shanafelt, Tait D., Strom, Sara S., Camp, Nicola J., Weinberg, J. Brice, Matutes, Estella, Caporaso, Neil E., Wade, Rachel, Dyer, Martin J.S., Dearden, Claire, Cerhan, James R., Catovsky, Daniel, and Houlston, Richard S.

Published
2012
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5. A Meta-Analysis Of Genome-Wide Association Studies Of Multiple Myeloma In Cases and Controls Of European Origin Identifies a Risk Locus In 12q23.1

Author

Rand, Kristin A, primary, Camp, Nicola, additional, Martino, Alessandro, additional, Dean, Eric W., additional, Serie, Daniel J., additional, Edlund, Christopher K., additional, Hu, Donglei, additional, Curtin, Karen, additional, Huntsman, Scott, additional, Van Den Berg, David J., additional, De Roos, Anneclaire, additional, Brown, Elizabeth E, additional, Giles, Graham G., additional, Spinelli, John J., additional, Ailawadhi, Sikander, additional, Birmann, Brenda M., additional, Brooks-Wilson, Angela R, additional, Severson, Richard K, additional, Bracci, Paige M, additional, Gebregziabher, Mulugeta, additional, Tomasson, Michael H., additional, Mohrbacher, Ann M., additional, Tricot, Guido J., additional, Campa, Daniele, additional, Martin, Thomas, additional, Henderson, Brian E., additional, Zangari, Maurizio, additional, Rothman, Nathaniel, additional, Chanock, Stephen Jacob, additional, Kumar, Shaji, additional, Kolonel, Laurence N., additional, Lee Wolf, Jeffrey, additional, Colditz, Graham A, additional, Rajkumar, S. Vincent, additional, Munshi, Nikhil C., additional, Anderson, Kenneth C., additional, Haiman, Christopher, additional, Conti, David V., additional, Canzian, Federico, additional, Vachon, Celine M, additional, Ziv, Elad, additional, and Cozen, Wendy, additional

Published
2013
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8. Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium

Author

Ekström Smedby, Karin, primary, Vajdic, Claire M., additional, Falster, Michael, additional, Engels, Eric A., additional, Martínez-Maza, Otoniel, additional, Turner, Jennifer, additional, Hjalgrim, Henrik, additional, Vineis, Paolo, additional, Seniori Costantini, Adele, additional, Bracci, Paige M., additional, Holly, Elizabeth A., additional, Willett, Eleanor, additional, Spinelli, John J., additional, La Vecchia, Carlo, additional, Zheng, Tongzhang, additional, Becker, Nikolaus, additional, De Sanjosé, Silvia, additional, Chiu, Brian C.-H., additional, Dal Maso, Luigino, additional, Cocco, Pierluigi, additional, Maynadié, Marc, additional, Foretova, Lenka, additional, Staines, Anthony, additional, Brennan, Paul, additional, Davis, Scott, additional, Severson, Richard, additional, Cerhan, James R., additional, Breen, Elizabeth C., additional, Birmann, Brenda, additional, Grulich, Andrew E., additional, and Cozen, Wendy, additional

Published
2008
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10. Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)

Author

Wang, Sophia S., primary, Slager, Susan L., additional, Brennan, Paul, additional, Holly, Elizabeth A., additional, De Sanjose, Silvia, additional, Bernstein, Leslie, additional, Boffetta, Paolo, additional, Cerhan, James R., additional, Maynadie, Marc, additional, Spinelli, John J., additional, Chiu, Brian C. H., additional, Cocco, Pier Luigi, additional, Mensah, Fiona, additional, Zhang, Yawei, additional, Nieters, Alexandra, additional, Dal Maso, Luigino, additional, Bracci, Paige M., additional, Costantini, Adele Seniori, additional, Vineis, Paolo, additional, Severson, Richard K., additional, Roman, Eve, additional, Cozen, Wendy, additional, Weisenburger, Dennis, additional, Davis, Scott, additional, Franceschi, Silvia, additional, La Vecchia, Carlo, additional, Foretova, Lenka, additional, Becker, Nikolaus, additional, Staines, Anthony, additional, Vornanen, Martine, additional, Zheng, Tongzhang, additional, and Hartge, Patricia, additional

Published
2006
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11. PRRC2Aand BCL2L11gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium

Author

Nieters, Alexandra, Conde, Lucia, Slager, Susan L., Brooks-Wilson, Angela, Morton, Lindsay, Skibola, Danica R., Novak, Anne J., Riby, Jacques, Ansell, Stephen M., Halperin, Eran, Shanafelt, Tait D., Agana, Luz, Wang, Alice H., De Roos, Anneclaire J., Severson, Richard K., Cozen, Wendy, Spinelli, John, Butterbach, Katja, Becker, Nikolaus, de Sanjose, Silvia, Benavente, Yolanda, Cocco, Pierluigi, Staines, Anthony, Maynadié, Marc, Foretova, Lenka, Boffetta, Paolo, Brennan, Paul, Lan, Qing, Zhang, Yawei, Zheng, Tongzhang, Purdue, Mark, Armstrong, Bruce, Kricker, Anne, Vajdic, Claire M., Grulich, Andrew, Smith, Martyn T., Bracci, Paige M., Chanock, Stephen J., Hartge, Patricia, Cerhan, James R., Wang, Sophia S., Rothman, Nathaniel, and Skibola, Christine F.

Abstract

Many common genetic variants have been associated with non-Hodgkin lymphoma (NHL), but individual study results are often conflicting. To confirm the role of putative risk alleles in B-cell NHL etiology, we performed a validation genotyping study of 67 candidate single nucleotide polymorphisms within InterLymph, a large international consortium of NHL case-control studies. A meta-analysis was performed on data from 5633 B-cell NHL cases and 7034 controls from 8 InterLymph studies. rs3789068 in the proapoptotic BCL2L11gene was associated with an increased risk for B-cell NHL (odds ratio = 1.21, Prandom = 2.21 × 10−11), with similar risk estimates for common B-cell subtypes. PRRC2Ars3132453 in the HLA complex class III region conferred a reduced risk of B-cell NHL (odds ratio = 0.68, Prandom = 1.07 × 10−9) and was likewise evident for common B-cell subtypes. These results are consistent with the known biology of NHL and provide insights into shared pathogenic components, including apoptosis and immune regulation, for the major B-cell lymphoma subtypes.

Published
2012
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12. A functional TNFRSF5gene variant is associated with risk of lymphoma

Author

Skibola, Christine F., Nieters, Alexandra, Bracci, Paige M., Curry, John D., Agana, Luz, Skibola, Danica R., Hubbard, Alan, Becker, Nikolaus, Smith, Martyn T., and Holly, Elizabeth A.

Abstract

CD40 and its ligand, CD154, are major costimulatory molecules whose interactions are important in humoral and cellular immunity. We hypothesized that single nucleotide polymorphisms (SNPs) in TNFRSF5and TNFSF5encoding the CD40 and CD154 proteins, respectively, influence lymphoma risk, particularly a functional TNFRSF5SNP (−1C>T, rs1883832) associated with reduced B-cell CD40 expression. TNFRSF5and TNFSF5SNPs were examined in a population-based case-control study of non-Hodgkin lymphoma (376 cases/801 controls with DNA), and compelling findings were followed up in 2 independent populations. Pooled analyses of all 3 case-control studies (total N = 1776 non-Hodgkin lymphoma cases, N = 2482 controls) revealed an increased risk of follicular lymphoma (FL) associated with the TNFRSF5−1TT genotype (odds ratio = 1.6; 95% confidence interval, 1.1-2.4). In addition, among women, an inverse association was found between the variant A allele for a TNFSF56809G>A SNP and FL risk (OR = .61; 95% CI, 0.36-0.98). In genotype-phenotype studies, significantly reduced circulating soluble CD40 was observed in TNFRSF5−1TT compared with −1CC carriers. Further, dendritic cells from those with −1TT versus −1CC genotypes exhibited lower CD40 cell surface expression. These results suggest that the TNFRSF5−1C>T polymorphism may increase FL susceptibility through mechanisms that hinder cellular immune responses. Further studies are needed to explore these findings.

Published
2008
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13. Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)

Author

Wang, Sophia S., Slager, Susan L., Brennan, Paul, Holly, Elizabeth A., De Sanjose, Silvia, Bernstein, Leslie, Boffetta, Paolo, Cerhan, James R., Maynadie, Marc, Spinelli, John J., Chiu, Brian C. H., Cocco, Pier Luigi, Mensah, Fiona, Zhang, Yawei, Nieters, Alexandra, Dal Maso, Luigino, Bracci, Paige M., Costantini, Adele Seniori, Vineis, Paolo, Severson, Richard K., Roman, Eve, Cozen, Wendy, Weisenburger, Dennis, Davis, Scott, Franceschi, Silvia, La Vecchia, Carlo, Foretova, Lenka, Becker, Nikolaus, Staines, Anthony, Vornanen, Martine, Zheng, Tongzhang, and Hartge, Patricia

Abstract

A role for genetic susceptibility in non-Hodgkin lymphoma (NHL) is supported by the accumulating evidence of common genetic variations altering NHL risk. However, the pattern of NHL heritability remains poorly understood. We conducted a pooled analysis of 10 211 NHL cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph) to evaluate NHL risk among those with hematopoietic malignancies in first-degree relatives. Odds ratios (ORs) and 95% confidence intervals (CIs) of NHL and its subtypes were estimated from unconditional logistic regression models with adjustment for confounders. NHL risk was elevated for individuals who reported first-degree relatives with NHL (OR = 1.5; 95% CI = 1.2-1.9), Hodgkin lymphoma (OR = 1.6; 95% CI = 1.1-2.3), and leukemia (OR = 1.4; 95% CI = 1.2-2.7). Risk was highest among individuals who reported a brother with NHL (OR = 2.8; 95% CI = 1.6-4.8) and was consistent for all NHL subtypes evaluated. If a first-degree relative had Hodgkin lymphoma, NHL risk was highest if the relative was a parent (OR = 1.7; 95% CI = 1.0-2.9). If a first-degree relative had leukemia, NHL risk was highest among women who reported a sister with leukemia (OR = 3.0; 95% CI = 1.6-5.6). The pattern of NHL heritability appeared to be uniform across NHL subtypes, but risk patterns differed by specific hematopoietic malignancies and the sex of the relative, revealing critical clues to disease etiology.

Published
2007
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