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1. Epidemiology and geographic clustering of Erdheim-Chester disease in Italy and France

Author

Peyronel, Francesco, primary, Haroche, Julien, additional, Campochiaro, Corrado, additional, Pegoraro, Francesco, additional, Amoura, Zahir, additional, Tomelleri, Alessandro, additional, Mazzariol, Martina, additional, Papo, Matthias, additional, Cavalli, Giulio, additional, Benigno, Giuseppe D., additional, Fenaroli, Paride, additional, Grigoratos, Chrysanthos, additional, Mengoli, Maria C., additional, Bonometti, Arturo, additional, Berti, Emilio, additional, Savino, Gustavo, additional, Cives, Mauro, additional, Neri, Iria, additional, Pacinella, Gaetano, additional, Tuttolomondo, Antonino, additional, Marano, Massimo, additional, Muratore, Francesco, additional, Manfredi, Andreina, additional, Broccoli, Alessandro, additional, Zinzani, Pier L., additional, Didona, Biagio, additional, Massaccesi, Chiara, additional, Buono, Andrea, additional, Ammirati, Enrico, additional, Di Lernia, Vito, additional, Dagna, Lorenzo, additional, Vaglio, Augusto, additional, and Cohen-Aubart, Fleur, additional

Published
2023
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3. Allogeneic Hematopoietic Cell Transplantation in Advanced Phase Mycosis Fungoides and Sézary Syndrome: A Retrospective Analysis of 57 Consecutive Patients

Author

Cavallaro, Francesca, primary, Versino, Francesco, additional, Serpenti, Fabio, additional, Iacobelli, Simona, additional, Alberti Violetti, Silvia, additional, Saporiti, Giorgia, additional, Goldaniga, Maria, additional, Galassi, Giulia, additional, Bagnoli, Filippo, additional, Rampi, Nicolo', additional, Barbullushi, Kordelia, additional, Bosi, Alessandro, additional, Cassanello, Giulio, additional, Simontacchi, Gabriele, additional, Schiavone, Concetta, additional, Baldini, Luca, additional, Berti, Emilio, additional, and Onida, Francesco, additional

Published
2022
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7. Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases

Author

Willemze, Rein, Jansen, Patty M., Cerroni, Lorenzo, Berti, Emilio, Santucci, Marco, Assaf, Chalid, Canninga-van Dijk, Marijke R., Carlotti, Agnes, Geerts, Marie-Louise, Hahtola, Sonja, Hummel, Michael, Jeskanen, Leila, Kempf, Werner, Massone, Cesare, Ortiz-Romero, Pablo L., Paulli, Marco, Petrella, Tony, Ranki, Annamari, Peralto, José L. Rodriguez, Robson, Alistair, Senff, Nancy J., Vermeer, Maarten H., Wechsler, Janine, Whittaker, Sean, and Meijer, Chris J. L.M.

Published
2008
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9. Haploidentical Stem Cell Transplantation in Advanced Stage Mycosis Fungoides and Sézary Syndrome: A Report of Four Consecutive Cases from a Single Center

Author

Onida, Francesco, primary, Saporiti, Giorgia, additional, Valli, Viviana Beatrice, additional, Alberti Violetti, Silvia, additional, Grifoni, Federica Irene, additional, Goldaniga, Maria Cecilia, additional, Sciumè, Mariarita, additional, Baldini, Luca, additional, and Berti, Emilio, additional

Published
2019
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10. Total Skin Electron Beam Therapy in Patients with Advanced Cutaneous T Cell Lymphoma Undergoing Allogeneic Stem Cell Transplantation: A Single Centre Experience

Author

Valli, Viviana Beatrice, primary, Grillo Ruggieri, Filippo, additional, Saporiti, Giorgia, additional, Alberti Violetti, Silvia, additional, Schiavone, Concetta, additional, Grifoni, Federica Irene, additional, Goldaniga, Maria Cecilia, additional, Casarin, Francesca, additional, Ferla, Valeria, additional, Baldini, Luca, additional, Berti, Emilio, additional, and Onida, Francesco, additional

Published
2019
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11. Long-Term Outcome of Reduced Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Mycosis Fungoides and Sézary Syndrome: The Milan Experience

Author

Onida, Francesco, primary, Saporiti, Giorgia, additional, Alberti Violetti, Silvia, additional, Tagliaferri, Elena, additional, Grifoni, Federica, additional, Levati, Giorgia, additional, Fanoni, Daniele, additional, Orofino, Nicola, additional, Sciumè, Mariarita, additional, Cortelezzi, Agostino, additional, and Berti, Emilio, additional

Published
2018
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14. Molecular Analysis of Primary Cutaneous Aggressive T-Cell Lymphomas: the Epidermotropic CD8+, the Pleomorphic CD8+ and the Gamma Delta Subsets.

Author

Berti, Emilio, primary, Fanoni, Daniele, additional, Onida, Francesco, additional, Girgenti, Valentina, additional, Novara, Francesca, additional, Corti, Laura, additional, Venegoni, Luigia, additional, Viganò, Francesca, additional, Saporiti, Giorgia, additional, Zuffardi, Orsetta, additional, and Paulli, Marco, additional

Published
2012
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15. Gistic Evaluation in Sezary Syndrome

Author

Cristofoletti, Cristina, primary, Tocco, Valeria, additional, Narducci, Maria Grazia, additional, Scala, Enrico, additional, Berti, Emilio, additional, Frontani, Marina, additional, Lombardo, Giuseppe Alfonso, additional, Monopoli, Alessandro, additional, Citterich, Mauro Helmer, additional, Bresin, Antonella, additional, Picchio, Maria Cristina, additional, Russo, Giandomenico, additional, and Caprini, Elisabetta, additional

Published
2012
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16. Blastic Plasmacytoid Dendritic Cell Neoplasm: Clinical, Immunohistochemical and Molecular Evaluation of 23 Cases with Primary Cutaneous Involvement,

Author

Berti, Emilio, primary, Lucioni, Marco, additional, Onida, Francesco, additional, Novara, Francesca, additional, Caprini, Elisabetta, additional, Fiandrino, Giacomo, additional, Riboni, Roberta, additional, Fanoni, Daniele, additional, Vezzoli, Pamela, additional, Arra, Mariarosa, additional, Venegoni, Luigia, additional, Nicola, Marta, additional, Dallera, Elena, additional, Arcaini, Luca, additional, Saporiti, Giorgia, additional, Travaglino, Erica, additional, Boveri, Emanuela, additional, Zuffardi, Orsetta, additional, Russo, Giandomenico, additional, and Paulli, Marco, additional

Published
2011
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17. Twenty-one cases of blastic plasmacytoid dendritic cell neoplasm: focus on biallelic locus 9p21.3 deletion

Author

Lucioni, Marco, primary, Novara, Francesca, additional, Fiandrino, Giacomo, additional, Riboni, Roberta, additional, Fanoni, Daniele, additional, Arra, Mariarosa, additional, Venegoni, Luigia, additional, Nicola, Marta, additional, Dallera, Elena, additional, Arcaini, Luca, additional, Onida, Francesco, additional, Vezzoli, Pamela, additional, Travaglino, Erica, additional, Boveri, Emanuela, additional, Zuffardi, Orsetta, additional, Paulli, Marco, additional, and Berti, Emilio, additional

Published
2011
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18. EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma*

Author

Kempf, Werner, primary, Pfaltz, Katrin, additional, Vermeer, Maarten H., additional, Cozzio, Antonio, additional, Ortiz-Romero, Pablo L., additional, Bagot, Martine, additional, Olsen, Elise, additional, Kim, Youn H., additional, Dummer, Reinhard, additional, Pimpinelli, Nicola, additional, Whittaker, Sean, additional, Hodak, Emmilia, additional, Cerroni, Lorenzo, additional, Berti, Emilio, additional, Horwitz, Steve, additional, Prince, H. Miles, additional, Guitart, Joan, additional, Estrach, Teresa, additional, Sanches, José A., additional, Duvic, Madeleine, additional, Ranki, Annamari, additional, Dreno, Brigitte, additional, Ostheeren-Michaelis, Sonja, additional, Knobler, Robert, additional, Wood, Gary, additional, and Willemze, Rein, additional

Published
2011
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20. The Impact of Therapeutic Management and Prognostic Factors on the Outcome of Primary Cutaneous B-Cell Lymphomas (PCBCL) (IELSG 11 Study)

Author

Cortelazzo, Sergio, primary, Mian, Michael, additional, Cantonetti, Maria, additional, Sarris, Andreas, additional, Rossi, Andrea, additional, Rambaldi, Alessandro, additional, Lombardo, Giuseppe, additional, Pasini, Felice, additional, Ambrosetti, Achille, additional, Devizzi, Liliana, additional, Busetto, Mario, additional, Bairey, Osnat, additional, Berti, Emilio, additional, Martinelli, Giovanni, additional, Tsang, Richard, additional, Rudoy, Silvia, additional, Blum, Robert, additional, Ferreri, Andres JM, additional, Pinotti, Graziella, additional, Pogliani, Enrico, additional, and Zucca, Emanuele, additional

Published
2008
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21. Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation Represents a Feasible and Effective Treatment Strategy for Advanced Mycosis Fungoides and Sezary Syndrome.

Author

Soligo, Davide, primary, Onida, Francesco, additional, Saporiti, Giorgia, additional, Volpe, Aldo Della, additional, Marino, Cristian, additional, Annaloro, Claudio, additional, Rambaldi, Alessandro, additional, Bruno, Benedetto, additional, Berti, Emilio, additional, and Deliliers, Giorgio Lambertenghi, additional

Published
2006
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22. Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+regulatory T cells by 1,25-dihydroxyvitamin D3

Author

Penna, Giuseppe, Roncari, Andrea, Amuchastegui, Susana, Daniel, Kenn C., Berti, Emilio, Colonna, Marco, and Adorini, Luciano

Abstract

1,25-dihydroxyvitamin D3(1,25(OH)2D3) is a secosteroid hormone that renders dendritic cells (DCs) tolerogenic, favoring the induction of regulatory T cells. Induction of DCs with tolerogenic properties by 1,25(OH)2D3is associated with increased selective expression of immunoglobulin-like transcript 3 (ILT3), suggesting its involvement in the immunoregulatory properties of this hormone. Here we show an in vivo correlate of the increased ILT3 expression on DCs in healing psoriatic lesions following topical treatment with the 1,25(OH)2D3analog calcipotriol. Analysis of DC subsets reveals a differential regulation of ILT3 expression by 1,25(OH)2D3, with a marked up-regulation in myeloid DCs but no effect on its expression by plasmacytoid DCs. A regulatory role for ILT3 expressed on DCs is indicated by the increased interferon-γ (IFN-γ) secretion promoted by anti-ILT3 addition to cultures of DCs and T cells, but this effect is blunted in 1,25(OH)2D3-treated DCs, suggesting ILT3-independent mechanisms able to regulate T-cell activation. Although ILT3 expression by DCs is required for induction of regulatory T cells, DC pretreatment with 1,25(OH)2D3leads to induction of CD4+Foxp3+cells with suppressive activity irrespective of the presence of neutralizing anti-ILT3 monoclonal antibody (mAb), indicating that ILT3 expression is dispensable for the capacity of 1,25(OH)2D3-treated DCs to induce regulatory T cells.

Published
2005
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23. WHO-EORTC classification for cutaneous lymphomas

Author

Willemze, Rein, Jaffe, Elaine S., Burg, Günter, Cerroni, Lorenzo, Berti, Emilio, Swerdlow, Steven H., Ralfkiaer, Elisabeth, Chimenti, Sergio, Diaz-Perez, José L., Duncan, Lyn M., Grange, Florent, Harris, Nancy Lee, Kempf, Werner, Kerl, Helmut, Kurrer, Michael, Knobler, Robert, Pimpinelli, Nicola, Sander, Christian, Santucci, Marco, Sterry, Wolfram, Vermeer, Maarten H., Wechsler, Janine, Whittaker, Sean, and Meijer, Chris J. L. M.

Abstract

Primary cutaneous lymphomas are currently classified by the European Organization for Research and Treatment of Cancer (EORTC) classification or the World Health Organization (WHO) classification, but both systems have shortcomings. In particular, differences in the classification of cutaneous T-cell lymphomas other than mycosis fungoides, Sézary syndrome, and the group of primary cutaneous CD30+ lymphoproliferative disorders and the classification and terminology of different types of cutaneous B-cell lymphomas have resulted in considerable debate and confusion. During recent consensus meetings representatives of both systems reached agreement on a new classification, which is now called the WHO-EORTC classification. In this paper we describe the characteristic features of the different primary cutaneous lymphomas and other hematologic neoplasms frequently presenting in the skin, and discuss differences with the previous classification schemes. In addition, the relative frequency and survival data of 1905 patients with primary cutaneous lymphomas derived from Dutch and Austrian registries for primary cutaneous lymphomas are presented to illustrate the clinical significance of this new classification.

Published
2005
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24. Risk of Kaposi's Sarcoma-Associated Herpes Virus Transmission From Donor Allografts Among Italian Posttransplant Kaposi's Sarcoma Patients

Author

Parravicini, Carlo, Olsen, Sonja J., Capra, Maria, Poli, Francesca, Sirchia, Girolamo, Gao, Shou-Jiang, Berti, Emilio, Nocera, Arcangelo, Rossi, Edardo, Bestetti, Giovannina, Pizzuto, Massimo, Galli, Massimo, Moroni, Mauro, Moore, Patrick S., and Corbellino, Mario

Abstract

Kaposi's sarcoma–associated herpesvirus (KSHV) is a newly discovered herpes virus found in all forms of Kaposi's sarcoma (KS) including KS among immunosuppressed transplant patients. It is unknown whether this virus is transmitted by organ transplantation or is reactivated during immunosuppression among those patients infected before transplantation. To investigate the risk of KSHV transmission during organ transplantation, we conducted a case-control study of transplant recipients with and without KS matched to their respective donors. Sera were collected at time of transplantation and tested in a randomized and blinded fashion using four KSHV serologic assays testing for antibodies to both latent and lytic phase antigens. Ten (91%) of 11 organ recipients who developed KS were seropositive prior to transplantation by one or more of the assays compared with two (12%) of 17 control organ recipients (OR = 75, 95% CI = 4.7, 3500). KS cases were more likely to have been born in southern Italy where KS is endemic than the recipient controls or either donor group. Only four (36%) of 11 donors to case patients and three (18%) of 17 donors to control patients were seropositive (P = .38, two-tailed Fisher's exact test). KSHV transmission could not be ruled out for the single KS patient seronegative at transplantation and clear evidence for organ-related transmission was found for another KS patient outside of the case-control study. Antibodies to KSHV are detectable in the sera from most transplant recipients before initiation of immunosuppressive treatment suggesting that KS among immunosuppressed transplant patients is primarily due to virus reactivation. KSHV transmission, however, from an infected allograft can occur, and our study reports the first documented case of person-to-person transmission of KSHV.

Published
1997
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25. Molecular Analysis of Cutaneous B- and T-Cell Lymphomas

Author

Neri, Antonino, Fracchiolla, Nicola Stefano, Roscetti, Elena, Garatti, Silvia, Trecca, Dino, Boletini, Alketa, Perletti, Lucia, Baldini, Luca, Maiolo, Anna Teresa, and Berti, Emilio

Abstract

Among extranodal non-Hodgkin's lymphomas, primary cutaneous lymphomas (CLs) represent a consistent group of B- and T-cell malignancies. We investigated the arrangement of Ig and T-cell receptor (TCR) genes, together with the involvement of several oncogenes and the tumor-suppressor gene p53, in a panel of primary cutaneous B- and T-cell lymphomas (CBCLs and CTCLs). Southern blot analysis was performed to detect rearrangements of the Ig, c-myc, bcl-l, bcl-2, bcl-3, bcl-6, and the NFKB2/lyt-10 genes in 52 cases of CBCLs and of the TCR, bcl-3, and NFKB2/lyt-10 genes in 38 cases of CTCLs. fa/-1 gene deletions were analyzed in CTCLs by means of polymerase chain reaction (PCR). p53 gene mutations were assayed using PCR, single-strand conformation polymorphism analysis, and direct DNA sequencing in CBCL and CTCL cases. Clonal rearrangements of Ig genes or oncogenes were found in 25 of the 52 CBCLs. In particular, we detected rearrangements of the bc/-1 locus (2 cases), the bcl-2 gene (2 cases), the NFKB2/lyt-10 gene (2 cases), and the bcl-6gene (1 case); interestingly, 4 of these cases showed a germline arrangement of the Ig genes. Clonal rearrangements of TCR genes were detected in 37 of the 38 CTCLs. Rearrangements of the NFKB2/lyt-10 gene were present in 2 cases and taAl gene deletions in 3 CTCL cases; p53 gene mutations were detected in 1 CTCL case. Overall, our data indicate that (1) clonal rearrangement of Ig genes is frequently undetectable by means of Southern blot in CBCLs ( 60%); (2) genetic lesions are involved in a limited but significant fraction of primary CLs showing a molecular marker of clonality (13/62; 20%); and (3) rearrangements of the bcM, bcl-2, or bcl-6loci, associated with specific subsets of nodal lymphoid neoplasias, are rarely observed in CBCLs. Moreover, our results suggest that tal-1 gene deletions may play a pathogenetic role in non-acute T-cell malignancies and that, in the context of lymphoid malignancies, CLs may represent a favorable target for the possible oncogenic potential of the NFKB2/lyt-10 gene.

Published
1995
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