1. Specific class of intrapartum antibiotics relates to maturation of the infant gut microbiota: a prospective cohort study.
- Author
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Coker, MO, Hoen, AG, Dade, E, Lundgren, S, Li, Z, Wong, AD, Zens, MS, Palys, TJ, Morrison, HG, Sogin, ML, Baker, ER, Karagas, MR, Madan, JC, Coker, M O, Hoen, A G, Wong, A D, Zens, M S, Palys, T J, Morrison, H G, and Sogin, M L
- Subjects
GUT microbiome ,INFANTS ,COHORT analysis ,ANTIBIOTICS ,LONGITUDINAL method ,BACTERIA ,BIFIDOBACTERIUM ,FECES ,HYDROLASES ,LACTOBACILLUS ,DURATION of pregnancy ,RESEARCH funding ,RNA ,VAGINA ,ANTIBIOTIC prophylaxis ,GRAM-negative anaerobic bacteria ,SEQUENCE analysis ,MATERNAL exposure - Abstract
Objective: To evaluate the potential impact of intrapartum antibiotics, and their specific classes, on the infant gut microbiota in the first year of life.Design: Prospective study of infants in the New Hampshire Birth Cohort Study (NHBCS).Settings: Rural New Hampshire, USA.Population or Sample: Two hundred and sixty-six full-term infants from the NHBCS.Methods: Intrapartum antibiotic use during labour and delivery was abstracted from medical records. Faecal samples collected at 6 weeks and 1 year of age were characterised by 16S rRNA sequencing, and metagenomics analysis in a subset of samples.Exposures: Maternal exposure to antibiotics during labour and delivery.Main Outcome Measure: Taxonomic and functional profiles of faecal samples.Results: Infant exposure to intrapartum antibiotics, particularly to two or more antibiotic classes, was independently associated with lower microbial diversity scores as well as a unique bacterial community at 6 weeks (GUnifrac, P = 0.02). At 1 year, infants in the penicillin-only group had significantly lower α diversity scores than infants not exposed to intrapartum antibiotics. Within the first year of life, intrapartum exposure to penicillins was related to a significantly lower increase in several taxa including Bacteroides, use of cephalosporins was associated with a significantly lower rise over time in Bifidobacterium and infants in the multi-class group experienced a significantly higher increase in Veillonella dispar.Conclusions: Our findings suggest that intrapartum antibiotics alter the developmental trajectory of the infant gut microbiome, and specific antibiotic types may impact community composition, diversity and keystone immune training taxa.Tweetable Abstract: Class of intrapartum antibiotics administered during delivery relates to maturation of infant gut microbiota. [ABSTRACT FROM AUTHOR]- Published
- 2020
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