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The occlusion of the terminal aortic region was experimentally induced in 48 dogs. It has been shown that myocardial lesions localized predominantly in the papillary muscles and subendocardially appear already 3 hours after the occlusion. The number of the affected cardiomyocytes increases and their size enlarges. The duration of ischemia directly correlates with metabolic disturbances: changes in the function of adenylate cyclase system, ion imbalance, damages in the energy metabolism. Metabolic and morphologic changes are accompanied by disturbances in the cardiac function manifested in the decrease of myocardial contractility.