1. Very small photoluminescent gold nanoparticles for multimodality biomedical imaging
- Author
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Keng S. Liang, Hui Ru Tan, Eng Soon Tok, Cheng-Liang Wang, Yi-Yun Chen, Sheng-Feng Lai, Chung-Shi Yang, Hsiang-Hsin Chen, Yeukuang Hwu, Cyril Petibois, Giorgio Margaritondo, C. Y. Chen, Chia-Chi Chien, Wen-Chang Chen, Lai, ShengFeng, Chien, Chia-Chi, Chen, Wenchang, Chen, Hsianghsin, Chen, Yiyun, Wang, Cheng-Liang, Hwu, Yeukuang, Yang, Chungshi, Chen, Chunyu, Liang, Keng, Petibois, Cyril, Tan, Huiru, Tok, E S, and Margaritondo, G
- Subjects
Photoluminescence ,Materials science ,Light ,Metal Nanoparticles ,Nanoparticle ,Bioengineering ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Applied Microbiology and Biotechnology ,Mass Spectrometry ,radiation synthesis ,Mice ,Microscopy, Electron, Transmission ,Spectroscopy, Fourier Transform Infrared ,Microscopy ,Tumor Cells, Cultured ,Animals ,Humans ,Tissue Distribution ,Sulfhydryl Compounds ,Irradiation ,Cell Proliferation ,Mice, Inbred BALB C ,X-Rays ,Fatty Acids ,x-ray imaging ,cellular uptake ,Neoplasms, Experimental ,021001 nanoscience & nanotechnology ,Fluorescence ,0104 chemical sciences ,tumor development ,Colloidal gold ,Thermogravimetry ,Cancer cell ,cytotoxicity ,photoluminescence ,Gold ,Au nanoparticles ,0210 nano-technology ,Biotechnology ,Visible spectrum - Abstract
An original synthesis method based on X-ray irradiation produced gold nanoparticles (AuNPs) with two important properties for biomedical research: intense visible photoluminescence and very high accumulation in cancer cells. The nanoparticles, coated with MUA (11-mercaptoundecanoid acid), are very small (1.4 nm diameter); the above two properties are not present for even slightly larger sizes. The small MUA-AuNPs are non-cytotoxic (except for very high concentrations) and do not interfere with cancer cell proliferation. Multimodality imaging using visible light fluorescence and X-ray microscopy is demonstrated by tracing the nanoparticle-loaded tumor cells. (C) 2012 Elsevier Inc. All rights reserved.
- Published
- 2013
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