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Your search keyword '"Agarabi, Cyrus D."' showing total 1 results
Start Over Author "Agarabi, Cyrus D." Journal biotechnology & applied biochemistry
1 results on '"Agarabi, Cyrus D."'

1. Evaluation of butyrate-induced production of a mannose-6-phosphorylated therapeutic enzyme using parallel bioreactors.

Author

Madhavarao, Chikkathur N., Agarabi, Cyrus D., Wong, Lily, Müller‐Loennies, Sven, Braulke, Thomas, Khan, Mansoor, Anderson, Howard, and Johnson, Gibbes R.

Subjects
*MANNOSE 6-phosphate, *LYSOSOMAL storage diseases, *THERAPEUTICS, *BIOREACTORS, *THERAPEUTIC use of enzymes, *GLYCANS, *CAPILLARY electrophoresis
Abstract

Bioreactor process changes can have a profound effect on the yield and quality of biotechnology products. Mannose-6-phosphate (M6P) glycan content and the enzymatic catalytic kinetic parameters are critical quality attributes ( CQAs) of many therapeutic enzymes used to treat lysosomal storage diseases ( LSDs). Here, we have evaluated the effect of adding butyrate to bioreactor production cultures of human recombinant [ABSTRACT FROM AUTHOR]

Published
2014
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