1. HCS-Mikroskopie – ein Schlüssel zu intrazellulären Schmerzmechanismen
- Author
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Tim Hucho and Jörg Isensee
- Subjects
0301 basic medicine ,Chemistry ,Cell ,Pharmacology toxicology ,Endogeny ,Nanotechnology ,Cell biology ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Signalling ,Cellular heterogeneity ,medicine ,Nociceptive Neurons ,Intracellular signalling ,Molecular Biology ,030217 neurology & neurosurgery ,Biotechnology - Abstract
Pain sensitivity is strongly modulated by intracellular signalling. The analysis of pain signalling is hampered by small numbers of neurons, high cellular heterogeneity, and near absence of transfectability. HCS microscopy allowed us to proof that nociceptive neurons express specific signalling components, to analyze signalling activity of endogenous signalling components with single cell resolution, and thereby to suggest blockers of Nav1.7 as novel therapeutic approach to boost the efficacy of opioids.
- Published
- 2017
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