1. Simultaneous detection of multiple lower genital tract pathogens by an impedimetric immunochip.
- Author
-
Chiriacò MS, Primiceri E, De Feo F, Montanaro A, Monteduro AG, Tinelli A, Megha M, Carati D, and Maruccio G
- Subjects
- Antibodies, Immobilized chemistry, Biosensing Techniques instrumentation, Dielectric Spectroscopy instrumentation, Equipment Design, Female, Humans, Immunoassay instrumentation, Vaginosis, Bacterial diagnosis, Candida albicans isolation & purification, Candidiasis diagnosis, Chlamydia Infections diagnosis, Chlamydia trachomatis isolation & purification, Lab-On-A-Chip Devices, Streptococcal Infections diagnosis, Streptococcus agalactiae isolation & purification
- Abstract
Lower genital tract infections caused by both sexually and not-sexually transmitted pathogens in women are a key public health priority worldwide, especially in developing countries. Since standard analyses are time-consuming, appropriate therapeutic intervention is often neglected or delayed. Lab-on-chips and biosensors open new perspectives and offer innovative tools to simplify the diagnosis by medical staff, especially in countries with inadequate resources. Here we report a biosensing platform based on Electrochemical Impedance Spectroscopy (EIS) that allows multiplexed detection of Candida albicans, Streptococcus agalactiae and Chlamydia trachomatis with a single biochip, enabling a quick screening thanks to the presence of different immobilized antibodies, each specific for one of the different target pathogens., (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF