1. A possible mechanism of spontaneous involution of infantile hemangioma
- Author
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Yan An Wang, Huaming Zhu, Weimin Ye, Jiang-Hong Zheng, Lizhen Wang, Qin Zhou, Xiu-juan Yang, and Z.Y. Zhang
- Subjects
Mesenchymal Differentiation ,Pathology ,medicine.medical_specialty ,Mesenchymal stem cell ,Medicine (miscellaneous) ,Biology ,Agricultural and Biological Sciences (miscellaneous) ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,eye diseases ,body regions ,Endothelial stem cell ,Infantile hemangioma ,Endothelial cell apoptosis ,medicine ,Involution (medicine) ,cardiovascular diseases ,sense organs ,Stem cell ,Stem cell transplantation for articular cartilage repair - Abstract
Infantile hemangiomas are common vascular tumours which exhibit a rapid proliferating phase followed by spontaneously involuting for a long time. The formation and development mechanisms are not clear yet. Recent studies show that hemangioma-derived stem cells have multipotential differentiation abilities, including endothelial and mesenchymal differentiation. In addition, mesenchymal stem cell has the capability of inducing endothelial cell apoptosis, differentiating into adipocytes and triggering the involution of hemangiomas. Thus we hypothesize that mesenchymal stem cell may be the source of spontaneously regression of hemangiomas. Further investigations may be needed to develop potential therapeutic implications of mesenchymal stem cell in treating hemangiomas.
- Published
- 2009
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