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In this article, the authors focus on the role of Rhizopus oryzae, a fungus, in the production on nitric oxide in rat hepatocyte cell line RLN-10. They inform that aqueous extract of the fungus induces diaminofluorescein-FM diacetate staining in the cells and the accumulation of nitrite in cell culture medium. They mention that the fungus also increases nuclear translocation of nuclear factor-kappa (NF-kappa) B p65 after lipopolysaccharide treatment, a potent activator of NF-kappa B.

The article discusses the results of a study which examines the effect of nitric oxide on the in vivo and in vitro expression of vascular endothelial growth factor (VEGF) in the placenta of pregnant rats. The study showed a temporary decrease in VEGF mRNA expression by nitric oxide synthase (NOS) inhibitor but return to normal levels after 24 hours of treatment. It also revealed a decrease in VEGF expression in placental implants after co-treatment with NOS inhibitor and lipopolysaccharide.