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The article studies the synthesis of tetrahydroisoquinolines by enzymatic Pictet-Spengler reaction. The stydy uses an N-terminally truncated (S)-norcoclaurine synthase (NCS) from Coptis japonica expressed in Escherichia coli, where NCS catalyzes stereoselective Pictet-Spengler reaction for benzylisoquinoline alkaloid synthesis in plants. The study reflects versatility of the enzyme in synthesizing high yields of 6,7-dihydroxy-l-phenethyl-l,2,3,4-tetrahydroisoquinoline.

In this article, the author discusses a research related to the pyrosequencing analysis of microbiota in a traditional medieval sushi in Japan, Kaburazushi. Topics discussed include processing of archetypal Japanese sushi involves microbial fermentation, sushi kaburazushi is prepared by fermenting salted yellow tail, salted turnip, and malted rice, and traditional sushi production involves fermentation and maturation facilitated by naturally occurring microbes.

In this article, the author discusses a research related to the improvement of reticuline productivity from dopamine by using engineered Escherichia coli. Topics discussed include benzylisoquinoline alkaloids (BIAs) are pharmaceutically important compounds, microbial production, and (S)-norcoclaurine synthase. Other topics discussed include BIAs are secondary metabolites synthesized by plants in Papaveraceae, Berberidaceae, Ranunculaceae, and Magnoliaceae families.