1. Pinctada fucata mantle gene 5 (PFMG5) from pearl oyster mantle inhibits osteoblast differentiation
- Author
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Zhao Wang, Shangfeng Liu, Stephen M. Hinshaw, and Xiaoyan Wang
- Subjects
musculoskeletal diseases ,Cellular differentiation ,Applied Microbiology and Biotechnology ,Biochemistry ,3T3 cells ,Analytical Chemistry ,Mice ,medicine ,Animals ,Pinctada fucata ,Pinctada ,Mantle (mollusc) ,Molecular Biology ,Gene ,Osteoblasts ,biology ,Chemistry ,Organic Chemistry ,Proteins ,Osteoblast ,Cell Differentiation ,General Medicine ,Anatomy ,3T3 Cells ,biology.organism_classification ,Cell biology ,medicine.anatomical_structure ,Alkaline phosphatase ,Biotechnology - Abstract
PFMG5 (Pinctada fucata mantle gene 5) was identified from mantle tissue of the pearl oyster, Pinctada fucada (P. fucada). Here we report that PFMG5 decreased osteoblast differentiation marker alkaline phosphatase (ALP) activity and the transcript levels of osteoblast differentiation specific marker genes in MC3T3-E1 cells. PFMG5 was identified as a new molecule inhibiting osteoblast differentiation.
- Published
- 2011