1. Olive leaf extract prevents cartilage degeneration in osteoarthritis of STR/ort mice
- Author
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Nomura Yoshihiro, Matsuda Hiroshi, Maruyama Takuma, Kamihama Haruka, Watanabe Mutsuto, Matsuda Kenshiro, Matsuo Toshiki, and Tanaka Akane
- Subjects
Cartilage, Articular ,Male ,0301 basic medicine ,medicine.medical_specialty ,Olive leaf extract ,Stimulation ,Osteoarthritis ,Hindlimb ,Severity of Illness Index ,Applied Microbiology and Biotechnology ,Biochemistry ,Cell Line ,Analytical Chemistry ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Olea ,Internal medicine ,Animals ,Medicine ,Hyaluronic Acid ,Molecular Biology ,Cartilage degeneration ,Plant Extracts ,business.industry ,Synovial Membrane ,Organic Chemistry ,General Medicine ,Osteoarthritis, Knee ,medicine.disease ,In vitro ,Molecular Weight ,Plant Leaves ,030104 developmental biology ,Endocrinology ,chemistry ,Synovial Cell ,030220 oncology & carcinogenesis ,Dietary Supplements ,Disease Progression ,Hydroxytyrosol ,Female ,business ,Biotechnology - Abstract
The chondroprotective effect of olive leaf extract (OLE) on knee osteoarthritis (OA) was studied with STR/ort mice (n = 5). OLE was administrated with a dosage of 100 mg/kg for 8 weeks and the OA severity score of hind limb knee joints was then measured. The Mankin scores of the knee joints of the non-OA control group, OA control group and OLE-treated group were 3.50, 11.13 and 7.20, respectively. This suggests that oral OLE supplements help prevent cartilage degeneration in STR/ort mice. In vitro, the synthesis of high molecular weight hyaluronan in synovial cells (HIG-82) was increased by OLE stimulation. This suggests that OLE modulates hyaluronan metabolism in synovial cells and improves OA symptoms. Our findings indicate that OLE intake inhibits cartilage destruction by increasing high molecular weight hyaluronan and thus preventing OA progress.
- Published
- 2018