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Introduction: For the clinical laboratory is important to have a sample that meets the requirements for analysis, reason why the clinical chemistry laboratory demands its patients to fast 8 hours in order to take the urea, creatinine and ALT analyses since the metabolism of food may be reflected in the serum changes and may cause interference in the reading of these analytes. The purpose of this work is to review how much interference occurs when the sample is read 2 hours after breakfast. Materials and Methods: Total, pre and postprandial blood samples for ALT, urea and serum creatinine analysis were taken for this study in order to establish the possible interferences glucose, cholesterol and triglycerides may cause in the analysis. The ANOVA test was used for the variance analysis and interferogram was used in order to determine the type of interference and its significance. Results: ANOVA test showed no significant differences in the results and interferogram did not show significant differences for any of the analytes of interest in this study. Discussion: The ALT, urea and creatinine analysis in fed postpandrial conditions suffer positive interference in some patients due to glucose, cholesterol and triglycerides contained in the sample. This interference is not significant which suggests that it is not necessary to fast when the sample is going to be taken when it can be taken 2 hours after breakfast with a previous 8 hour fast. [ABSTRACT FROM AUTHOR]