1. Activity-induced gene expression in the human brain.
- Author
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Chatterjee S, Park BJ, Vanrobaeys Y, Heiney SA, Rhone AE, Nourski KV, Langmack L, Mukherjee U, Kovach CK, Kocsis Z, Kikuchi Y, Petkov CI, Hefti MM, Bahl E, Michaelson JJ, Kawasaki H, Oya H, Howard MA 3rd, Nickl-Jockschat T, Lin LC, and Abel T
- Abstract
Activity-induced gene expression underlies synaptic plasticity and brain function. Here, using molecular sequencing techniques, we define activity-dependent transcriptomic and epigenomic changes at the tissue and single-cell level in the human brain following direct electrical stimulation of the anterior temporal lobe in patients undergoing neurosurgery. Genes related to transcriptional regulation and microglia-specific cytokine activity displayed the greatest induction pattern, revealing a precise molecular signature of neuronal activation in the human brain., Competing Interests: Competing interests T.A. is a scientific advisor to Aditum Bio and Radius Health and he serves on the scientific advisory board of Embark Neuro. T.A serves on the Scientific Advisory Board of EmbarkNeuro and is a scientific advisor to Aditum Bio and Radius Health. The other authors declare no conflicting interests.
- Published
- 2023
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