1. Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers
- Author
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Diego Tesauro, Antonella Accardo, Giancarlo Morelli, Carlo Pedone, Gaetano Mangiapia, Accardo, Antonella, Tesauro, Diego, Mangiapia, G., Pedone, Carlo, and Morelli, Giancarlo
- Subjects
Circular dichroism ,Biophysics ,Nanotechnology ,Peptide ,Antineoplastic Agents ,Microscopy, Atomic Force ,Biochemistry ,Sincalide ,peptide amphiphile ,Biomaterials ,Surface-Active Agents ,Amphiphile ,Scattering, Small Angle ,Peptide amphiphile ,CD circular dichroism ,chemistry.chemical_classification ,Drug Carriers ,SANS ,Chemistry ,Circular Dichroism ,Organic Chemistry ,General Medicine ,Combinatorial chemistry ,Small-angle neutron scattering ,Nanostructures ,Neutron Diffraction ,Spectrometry, Fluorescence ,Doxorubicin ,drug delivery ,Drug delivery ,Drug carrier ,Self-assembling peptide - Abstract
The self-assembling behavior, at physiological pH, of the amphiphile peptide (C18)2L5CCK8 in nanostructures is reported. Stable aggregates presenting a critical micellar concentration of 2 × 10−6 mol kg−1, and characterized by water exposed CCK8 peptide in β-sheet conformation, are obtained. Small angle neutron scattering experiments are indicative for a 3D structure with dimensions ≥100 nm. AFM images confirm the presence of nanostructures. Fluorescence experiments indicating the sequestration of pyrene, chosen as drug model, and the anticancer Doxorubicin within the nanostructures are reported. © 2006 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 88: 115–121, 2007. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
- Published
- 2006