1. The inhibition of NF-kB activation decreases the resistance of acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates
- Author
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Irina Fadeeva, Vladimir S. Akatov, R. S. Fadeev, A. K. Golenkov, A. S. Senotov, S. G. Zakharov, M. E. Solovieva, and D. A. Slyadovskiy
- Subjects
0301 basic medicine ,Myeloid ,Biophysics ,Myeloid leukemia ,Biology ,medicine.disease ,NFKB1 ,03 medical and health sciences ,Leukemia ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Apoptosis ,hemic and lymphatic diseases ,030220 oncology & carcinogenesis ,medicine ,Cancer research ,Phosphorylation ,Cytotoxic T cell ,Transcription factor - Abstract
Suppression of resistance in acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates, was studied using small molecule inhibitors of the activation of the transcription factor NF-kB - NF-k9 Activation Inhibitor IV and JSH-23 at non-toxic concentrations. NF-kB Activation Inhibitor IV and JSH-23 reduced resistance in the acute myeloid leukemia cells in multicellular aggregates to cytotoxic action of recombinant protein izTRAIL. It is shown that the use of these inhibitors decreased the phosphorylation of the RelA (p65) as a main marker activation of the transcription factor NF-kB. We discuss a possible reason for increasing resistance in acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates.
- Published
- 2015
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