1. COMPARISON OF ANTIMICROBIAL PROPERTIES OF NANO QUINOLONE WITH ITS MICROSCALE EFFECTS.
- Author
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BEHBAHANl, G. REZAIE, SADR, M. HOSSAINI, NABIPOUR, H., BEHBAHANl, H. REZAIE, VAHEDPOUR, M., and BARZEGAR, L.
- Subjects
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ANTI-infective agents , *QUINOLONE antibacterial agents , *X-ray diffraction , *CARBON tetrachloride , *SCANNING electron microscopes , *HUMAN body , *GRAM-positive bacteria - Abstract
Nano nalidixic acid was prepared by ultrasonic method in carbon tetrachloride. Nano nalidixic acid (quinolone antibiotic) was characterized by X-ray diffraction (XRD), infrared spectroscopy (IR) and scanning electron microscope (SEM). The antibacte-rial activities of nano nalidixic acid were tested against microorganisms and compared with the microscale drug. The results show that nano nalidixic acid has good inhibitory properties against two Gram-positive species, Staphylococcus aureus and Bacillus sub-tilis. Nano nalidixic acid also showed good antifungal activity against Candida albicans. Nano nalidixic acid can be injected into the human body as a decontaminating agent to prevent the growth of harmful microorganisms more effectively than the micro-sized drug. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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