50 results on '"Sakurai, Takashi"'
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2. Arrhythmia severity in mouse models harboring RyR2 mutations with varied extent of channel activity
3. High-throughput platform of reconstituted skeletal muscle depolarization-induced Ca2+release in HEK293 cells
4. Differential impacts of arrhythmia-linked loss-of-function RyR2 mutations on Ca2+ signaling in cardiac cells
5. Effects of RyR2 Inhibitors on Ca2+ Signals in Healthy and Diseased Cardiac Cells
6. Characterization of Novel RyR1-Selective Inhibitors Identified by High-Throughput Screening using ER Ca2+ Measurement
7. Elucidation of Mechanism of Ca2+Induced Ca2+Release of Ryr2 Revealed by Cryo-EM
8. Molecular Dynamics and Ca2+ Imaging of Mutant Type 1 Ryanodine Receptor
9. Improvements of ER-Ca2+ Based High-Throughput Screening Method for Searching Novel RyR2 Inhibitors
10. Investigation of Mutant Ryanodine Receptor Channel Activity using Functional Analysis and Molecular Dynamics
11. The Effects of Frequency of Voluntary Exercise on Cardiac Function in Dilated Cardiomyopathy Model Mice
12. Efficient High-Throughput Screening for Type 1 Ryanodine Receptor Inhibitors using ER Ca2+Measurements
13. Structure Development of Oxolinic Acid, a Novel Inhibitor of Type 1 Ryanodine Receptor (RyR1) Ca2+ Release Channel
14. Identification of Novel RyR1 Inhibitors by High-Throughput Screening using ER Ca2+ Measurement
15. Effects of Novel RyR2 Inhibitors on Diseased Hearts
16. Pivotal role of S5 segment and S5–S6 luminal loop in the channel gating of type 1 ryanodine receptor (RyR1)
17. Effects of a high-affinity and selective RyR2 inhibitor on Ca2+signals in cardiomyocytes and arrhythmias in CPVT model mice
18. Search for Type 2 Ryanodine Receptor Inhibitor by Monitoring Endoplasmic Reticulum Ca2+
19. Therapeutic Effects of Ghrelin and Des-Acyl Ghrelin on Doxorubicin-Induced Cardiotoxicity
20. Relation between Voluntary Exercise Frequency and Cardiac Function in Dilated Cardiomyopathy Model Mice
21. Molecular Basis for Ca2+ Binding of RyR2 for Channel Activation and Diseases States
22. Regulation of Store Ca2+ Level in HEK293 Cells Expressing Type 2 Ryanodine Receptor (RyR2) with CPVT Mutations
23. Effects of Expression Levels of WT and Mutant RyR2 on Ca 2+ Homeostasis in HEK Cells
24. Effects of Ghrelin and Des-Acyl Ghrelin on Doxorubicin-Induced Cardiac Toxicity
25. The Comparison of Voluntary and Forced Exercises on Cardiac Function of DCM Model Mice
26. Modulation of Ca 2+ Signaling in HL-1 Cardiomyocytes by Arrhythmogenic RyR2 Mutants
27. Genotype-Phenotype Correlations of the Central Core Disease Mutations in the C-Terminal Region of the RyR1 Channel
28. S4-S5 Linker Regulates RyR2 Channel Gating through Multiple Interactions
29. The Benefits of Voluntaly Exersice on Cardiac Function in DCM Model Mice
30. Characterization of Ca2+-Induced Ca2+ Release via RyR2 Carrying Arrhythmogenic Mutations
31. Effects of MH and CCD Mutations in the Central Region on RyR1 Channels
32. Proteins in Striated Muscles that Transcribed from the Contiguous Region of Connectin Gene
33. Effects of Arrhythmogenic Mutations on Ca2+-Induced Ca2+ Release Activities of Type 2 Ryanodine Receptors
34. Effects of Amino-Terminal Disease-Associated Mutations on the CICR Activity of RyR1 Channel
35. Divergent Effects of Disease-Associated Mutations on Type 2 Ryanodine Receptor Channel
36. Effects of Angiotensin II Receptor Blocker on the Progression of Electrical Remodeling in Hearts of Inherited DCM Model Mice
37. Multistep Electrical Remodeling and Sudden Death Precede Heart Failure in a Mouse Model of Inherited Dilated Cardiomyopathy
38. Ion Channel Remodeling in Failing and Non-Failing Hearts of Inherited DCM Mouse Model -Usefulness of Running Wheel in Detection of Heart Failure-
39. Role of Amino-Terminal Half of the S4-S5 Linker in the RyR1 Channel Gating
40. Reconstitution of depolarization-induced Ca2+release for validation of skeletal muscle disease mutations and drug discovery
41. Effects of voluntary exercise and administration of renin angiotensin inhibitor on cardiac function in inherited dilated cardiomyopathy model
42. Mechanisms of Lethal Arrhythmia in Dilated Cardiomyopathy Model Mice
43. Effects of Voluntary Exercise on Viability and Electrical Remodeling in DCN Model Mice
44. Arrhythmogenic Activity and Channel Remodeling in Ventricles of Dilated Cardiomyopathy (DCM) Model Mice
45. Water Secretion Associated with Exocytosis in Endocrine Cells Revealed by Micro Forcemetry and Evanescent Wave Microscopy
46. Differential impacts of arrhythmia-linked loss-of-function RyR2 mutations on Ca2+signaling in cardiac cells
47. Modulation of Ca2+Signaling in HL-1 Cardiomyocytes by Arrhythmogenic RyR2 Mutants
48. Effects of Expression Levels of WT and Mutant RyR2 on Ca2+Homeostasis in HEK Cells
49. Characterization of Ca2+-Induced Ca2+Release via RyR2 Carrying Arrhythmogenic Mutations
50. Effects of Arrhythmogenic Mutations on Ca2+-Induced Ca2+Release Activities of Type 2 Ryanodine Receptors
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