1. Studies on antimicrobial effects of four ligands and their transition metal complexes with 8-mercaptoquinoline and pyridine terminal groups
- Author
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Yu Li, Jing-An Zhang, Ning Li, Li-Jie Zhang, Xun-Zhong Zou, Ya-Jie Liu, and Zi-Jie Zhang
- Subjects
Gram-negative bacteria ,Stereochemistry ,Pyridines ,Gram-positive bacteria ,Clinical Biochemistry ,Molecular Conformation ,Pharmaceutical Science ,Microbial Sensitivity Tests ,medicine.disease_cause ,Crystallography, X-Ray ,Gram-Positive Bacteria ,Ligands ,Biochemistry ,Structure-Activity Relationship ,Anti-Infective Agents ,Coordination Complexes ,Drug Discovery ,Fusarium oxysporum ,Gram-Negative Bacteria ,medicine ,Transition Elements ,Organic chemistry ,Molecular Biology ,Escherichia coli ,biology ,Chemistry ,Pseudomonas aeruginosa ,Organic Chemistry ,Aspergillus niger ,Fungi ,biology.organism_classification ,Antimicrobial ,Staphylococcus aureus ,Quinolines ,Molecular Medicine - Abstract
Four types of ligands (Q1–Q4) and their complexes ( 1 – 36 ) with transition metal ions have been synthesized, in which two new complexes ( 15 and 20 ) have been prepared and tested. In vitro antimicrobial activities of the ligands and their complexes were investigated against a representative panel of strains including two Gram positive bacteria ( Sarcina ureae , Staphylococcus aureus ), two Gram negative bacteria ( Escherichia coli , Pseudomonas aeruginosa ) and three fungi ( Aspergillus niger , Saccharomyces cerevisiae , Fusarium oxysporum f. sp. cubense ). The relationship between the structure and the antibacterial activities was discussed. Our study results indicated that some compounds have preferred antibacterial activities that may have potential pharmaceutical applications.
- Published
- 2014