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Start Over Author "Vera Seidl" Journal bioorganicmedicinal chemistry letters
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1. Synthesis and structure-activity relationships of oxime neurokinin antagonists: discovery of potent arylamides

Author

Shih Neng-Yang, Grice Cheryl A, Margaret M. Albanese, John H. Schwerdt, Carruthers Nicholas I, Ling Lin, Vera Seidl, John C. Anthes, Piwinski John J, Gregory A. Reichard, Shing-Chung Wong, and Pietro Mangiaracina

Subjects
medicine.drug_class, Stereochemistry, Aryl, Organic Chemistry, Clinical Biochemistry, Antagonist, Pharmaceutical Science, Ether, Carboxamide, Receptors, Neurokinin-2, Oxime, Biochemistry, Chemical synthesis, In vitro, chemistry.chemical_compound, Structure-Activity Relationship, chemistry, Neurokinin-1 Receptor Antagonists, Drug Discovery, Oximes, medicine, Molecular Medicine, Molecular Biology
Abstract

The structural modification of the benzylic ether region of oxime 1 has resulted in the identification of several novel aryl amides as selective or dual NK 1 /NK 2 antagonists.

Published
2002

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