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Start Over Author "Supaporn Seetaha" Journal bioorganicmedicinal chemistry letters
1 results on '"Supaporn Seetaha"'

1. Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation

Author

Nattanan Jiwacharoenchai, Rungroj Saruengkhanphasit, Worawat Niwetmarin, Supaporn Seetaha, Kiattawee Choowongkomon, Somsak Ruchirawat, and Chatchakorn Eurtivong

Subjects
Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, National Cancer Institute (U.S.), United States, ErbB Receptors, Molecular Docking Simulation, Oxygen, Structure-Activity Relationship, Xanthenes, Heterocyclic Compounds, Cell Line, Tumor, Drug Discovery, Molecular Medicine, Humans, Drug Screening Assays, Antitumor, Molecular Biology, Protein Kinase Inhibitors, Cell Proliferation
Abstract

A similarity search was conducted on the U.S. Enhanced National Cancer Institute Database Browser 2.2 to find structures related to 1,5-dihydroxy-9H-xanthen-9-one, a previously established EGFR-TK inhibitor. Compounds were virtually screened and selected for bioactivity testing revealed 5 candidates, mostly displayed stronger antiproliferative activities than erlotinib with IC

Published
2021

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