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Your search keyword '"Shoufa Han"' showing total 3 results
Start Over Author "Shoufa Han" Journal bioorganicmedicinal chemistry letters
3 results on '"Shoufa Han"'

1. Metabolic installation of macrophage-recruiting glycan ligand on tumor cell surface for in vivo tumor suppression

Author

Yunzhi Xie, Yibao Li, and Shoufa Han

Subjects
Lung Neoplasms, Sialic Acid Binding Ig-like Lectin 1, Macrophages, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Glycocalyx, Ligands, Biochemistry, Mice, Inbred C57BL, Metabolic Engineering, Cell Line, Tumor, Drug Discovery, Sialic Acids, Molecular Medicine, Animals, Molecular Biology, Melanoma, Cell Proliferation
Abstract

Synthetic probes that could direct immune cells against tumors are potential immunotherapeutics. We herein report in vivo tumor suppression via an intravenously injected abiotic sialic acid (

Published
2021

2. Liposome-aided metabolic engineering of tumor surface immunogenicity

Author

Shoufa Han, Siyu Wang, Xinhui Su, and Nianfeng Zheng

Subjects
0301 basic medicine, Clinical Biochemistry, Cell, Pharmaceutical Science, Biotin, Mice, Nude, Oligosaccharides, 010402 general chemistry, 01 natural sciences, Biochemistry, Metabolic engineering, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Tissue Distribution, Molecular Biology, Liposome, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Molecular Structure, Immunogenicity, Organic Chemistry, Neoplasms, Experimental, In vitro, N-Acetylneuraminic Acid, 0104 chemical sciences, Sialic acid, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, chemistry, Metabolic Engineering, Biotinylation, Antigens, Surface, Liposomes, NIH 3T3 Cells, Molecular Medicine, Immunotherapy
Abstract

Approaches to increase tumor immunogenicity are of therapeutic potentials. We herein reported the use of liposomes for covalent incorporation of neoantigen on tumor surfaces with DNP-conjugated sialic acid (DNPSia). Relative to free DNPSia, sugar-encapsulated biotinylated liposomes (DNPSia@LP@biotin) enables effective cell surface expression of DNPSia on biotin receptor (BR)-expressing cells over BR-free cells in vitro, and on tumor cell surfaces with high tumor-to-normal tissue contrast in a mice model. These findings suggest the potentials of targetable liposomes for modulating tumor surface immunity via metabolic oligosaccharide engineering.

Published
2018

3. Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates

Author

Xiaoping Chen, Tong Chen, Shoufa Han, Weijun Fang, Rongmin Su, Quanli Yang, Ningshao Xia, Yijun Cai, Jiahuai Han, and Lei Li

Subjects
Maleic acid, Anti-HIV Agents, Clinical Biochemistry, Pharmaceutical Science, HIV Infections, Biochemistry, Chemical synthesis, Cell Line, chemistry.chemical_compound, Hydrolysis, Microbicide, Drug Discovery, Moiety, Organic chemistry, Humans, Molecular Biology, Organic Chemistry, Maleates, Maleic anhydride, Biological activity, Microbicides for sexually transmitted diseases, chemistry, Anti-Infective Agents, Local, Molecular Medicine, Polystyrenes, HeLa Cells
Abstract

Topical microbicides offer women the opportunity to protect themselves from sexual HIV transmission under their own control. A series of poly[styrene-alt-(maleic anhydride)] derivatives were prepared by amidation or hydrolysis of the anhydride moiety. The derivatives were shown to be of low cell toxicity and effectively inhibited HIV-1 infections in an in vitro cellular model. Poly[styrene-alt-(maleic acid, sodium salt)] was the most potent inhibitor, being 100-fold more potent than dextran sulfate suggesting its potential application as a new class of polyanionic microbicides.

Published
2008

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