1. Anthraquinone derivatives from Rumex plants and endophytic Aspergillus fumigatus and their effects on diabetic nephropathy
- Author
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Yong-Xian Cheng, Lan-Sheng Zhang, Yong-Xun Yang, Wei Wei, Xiao-Jiang Zhou, Jie Luo, Yong-Ming Yan, Yang Yang, and Pengcheng Wang
- Subjects
Cell Survival ,Endophytic Aspergillus fumigatus ,Clinical Biochemistry ,Pharmaceutical Science ,Anthraquinones ,Diabetic nephropathy ,Naphthalenes ,Biochemistry ,Anthraquinone ,Aspergillus fumigatus ,Microbiology ,chemistry.chemical_compound ,Structure-Activity Relationship ,Drug Discovery ,medicine ,Structure–activity relationship ,Humans ,Diabetic Nephropathies ,Glycosides ,Rumex ,Renal Insufficiency, Chronic ,Molecular Biology ,biology ,Dose-Response Relationship, Drug ,Molecular Structure ,Chemistry ,Rumex patientia ,Interleukin-6 ,Organic Chemistry ,Absolute configuration ,Oxanthrone C-glycoside ,biology.organism_classification ,medicine.disease ,Extracellular Matrix ,Mesangial Cells ,Molecular Medicine - Abstract
Two new oxanthrone C-glycosides, patientosides A (14) and B (15), together with three known ones (11-13), were isolated from Rumex patientia. Their structures were identified on the basis of spectroscopic methods. The absolute configuration for 14 and 15 were deduced by analysis of their CD spectra and comparison with those of known similar compounds. Compounds 11-15, and 14 known anthraquinones (1-4, 6-10, 16-20) previously isolated from Rumex nepalensis, Rumex hastatus, and endophytic Aspergillus fumigatus, respectively, as well as a commercially available compound rhein (5) were evaluated for their inhibitory effects on IL-6 and extracellular matrix production in mesangial cells. (c) 2013 Elsevier Ltd. All rights reserved.
- Published
- 2013