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Your search keyword '"L. Manmohan Reddy"' showing total 1 results
Start Over Author "L. Manmohan Reddy" Journal bioorganicmedicinal chemistry letters
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1. 11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression

Author

Y. Krishna Reddy, U. Murali Krishna, Muralidhar Bondlela, Yu Ji, Jianxin Sun, John R. Falck, L. Manmohan Reddy, and James K. Liao

Subjects
Clinical Biochemistry, Pharmaceutical Science, Vascular Cell Adhesion Molecule-1, Epoxyeicosatrienoic acid, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, 8,11,14-Eicosatrienoic Acid, Drug Discovery, medicine, Animals, Humans, VCAM-1, Molecular Biology, Binding Sites, Molecular Structure, Cell adhesion molecule, Tumor Necrosis Factor-alpha, Organic Chemistry, In vitro, Endothelial stem cell, medicine.anatomical_structure, chemistry, Eicosanoid, cardiovascular system, Molecular Medicine, lipids (amino acids, peptides, and proteins), Endothelium, Vascular, Blood vessel, Binding domain
Abstract

A series of 11,12-EET analogues were synthesized and compared using a human endothelial cell based TNF-alpha-induced VCAM-1 expression assay. The resulting data were used to map a putative recognition/binding domain for 11,12-EET.

Published
2003

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