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Start Over Author "Anton Bunschoten" Journal bioorganicmedicinal chemistry
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1. Synthesis and evaluation of chloromethyl sulfoxides as a new class of selective irreversible cysteine protease inhibitors

Author

Anton Bunschoten, Rob M. J. Liskamp, and Arwin J. Brouwer

Subjects
Models, Molecular, Proteases, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Cysteine Proteinase Inhibitors, Crystallography, X-Ray, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Papain, Molecular Biology, Serine protease, chemistry.chemical_classification, Chymotrypsin, biology, Molecular Structure, Organic Chemistry, Stereoisomerism, Cysteine protease, Amino acid, chemistry, Enzyme inhibitor, Sulfoxides, biology.protein, Molecular Medicine, Cysteine
Abstract

The synthesis and biological evaluation of a new class of selective irreversible cysteine protease inhibitors is described. A set of amino acid based chloromethyl sulfoxides was prepared and they were found to inhibit irreversibly the cysteine protease papain. They were selective for cysteine proteases since no inhibition was found for the serine protease chymotrypsin.

Published
2007

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