1. Exploiting the furo[2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis.
- Author
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Fumagalli F, de Melo SMG, Ribeiro CM, Solcia MC, Pavan FR, and da Silva Emery F
- Subjects
- Amination, Antitubercular Agents chemistry, Microbial Sensitivity Tests, Pyridines pharmacology, Structure-Activity Relationship, Antitubercular Agents pharmacology, Drug Resistance, Multiple, Bacterial drug effects, Furans chemistry, Mycobacterium tuberculosis drug effects, Pyridines chemistry
- Abstract
Identification of new antibiotics suitable for the treatment of tuberculosis is required. In addition to selectivity, it is necessary to find new antibiotics that are effective when the tuberculous mycobacteria are resistant to the available therapies. The furo[2,3-b]pyridine core offers potential for this application. Herein, we have described the screening of our in-house library of furopyridines against Mycobacterium tuberculosis and identified a promising selective bioactive compound against different drug-resistant strains of this mycobacteria. The library of compounds was prepared by a CH amination reaction using mild and metal-free conditions, increasing the available information about the reactivity of furo[2,3-b]pyridine core through this reaction., (Copyright © 2019. Published by Elsevier Ltd.)
- Published
- 2019
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