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Start Over Author "Tosquellas, G" Journal bioorganic medicinal chemistry letters

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1. First synthesis of alternating SATE-phosphotriester/phosphodiester prooligonucleotides on solid support.

Author

Tosquellas G, Bologna JC, Morvan F, Rayner B, and Imbach JL

Subjects
Animals, Cell Extracts, Esterases metabolism, Half-Life, Liver enzymology, Liver metabolism, Swine, Thymidine chemistry, Oligonucleotides chemical synthesis
Abstract

Prooligonucleotides with alternating S-Acyl-ThioEthyl (SATE) phosphotriester and phosphodiester linkages or a gap were synthesized by elimination of cyanoethyl group with non-nucleophilic base DBU. Their half-lives in the presence of Pig Liver Esterases (PLE) and in total cell extract were determined.

Published
1998
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