1. An eco-friendly and water mediated product selective synthesis of 2-aminopyrimidines and their in vitro anti-bacterial evaluation.
- Author
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Nagarajan S, Shanmugavelan P, Sathishkumar M, Selvi R, Ponnuswamy A, Harikrishnan H, Shanmugaiah V, and Murugavel S
- Subjects
- Humans, In Vitro Techniques, Microbial Sensitivity Tests, Molecular Structure, Structure-Activity Relationship, Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents pharmacology, Escherichia coli drug effects, Klebsiella pneumoniae drug effects, Pyrimidines chemistry, Pyrimidines pharmacology, Staphylococcus aureus drug effects, Water chemistry
- Abstract
A greener water mediated protocol for the efficient synthesis of a library of 2-amino-6-styryl pyrimidines (4) and their dihydro analogues (3) has been reported. Most of the saturated compounds (3) rather than their unsaturated analogues (4) showed better anti-bacterial (in vitro) activity against three human pathogens viz. Staphylococcus aureus, Klebsiella pneumonia and Escherichia coli. In particular, three of them (3 b, 3 i &3 k) exhibited high inhibition against the growth of all the three pathogens comparable with that of the reference drug, tetracycline., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2014
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