1. 1,4-Benzodiazepine peripheral cholecystokinin (CCK-A) receptor agonists.
- Author
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Sherrill RG, Berman JM, Birkemo L, Croom DK, Dezube M, Ervin GN, Grizzle MK, James MK, Johnson MF, Queen KL, Rimele TJ, Vanmiddlesworth F, and Sugg EE
- Subjects
- Animals, Gallbladder drug effects, Guinea Pigs, In Vitro Techniques, Rats, Rats, Long-Evans, Receptor, Cholecystokinin A, Satiety Response drug effects, Appetite Depressants chemical synthesis, Appetite Depressants pharmacology, Benzodiazepines chemical synthesis, Benzodiazepines pharmacology, Receptors, Cholecystokinin agonists
- Abstract
A series of 1,4-benzodiazepines, N-1-substituted with an N-isopropyl-N-phenylacetamide moiety, was synthesized and screened for CCK-A agonist activity. In vitro agonist activity on isolated guinea pig gallbladder along with in vivo induction of satiety following intraperitoneal administration in a rat feeding assay was demonstrated.
- Published
- 2001
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