1. Novel peptidomimetic hematoregulatory compounds.
- Author
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Heerding DA, Abruzzese M, Alberts D, Burgess J, Callahan JF, Huffman WF, King AG, LoCastro S, DeMarsh P, Pelus LM, Takata JS, and Bhatnagar PK
- Subjects
- Amino Acids chemistry, Animals, Candidiasis drug therapy, Cardiovascular Agents pharmacology, Cardiovascular Agents therapeutic use, Cell Line, Chemokine CXCL1, Chemotactic Factors metabolism, Drug Design, Granulocyte Colony-Stimulating Factor biosynthesis, Granulocyte-Macrophage Colony-Stimulating Factor biosynthesis, Growth Substances metabolism, Macrophage Colony-Stimulating Factor biosynthesis, Mice, Oligopeptides chemistry, Receptors, Drug chemistry, Receptors, Drug drug effects, Cardiovascular Agents chemical synthesis, Chemokines, CXC, Intercellular Signaling Peptides and Proteins, Oligopeptides pharmacology
- Abstract
The activity of a novel series of peptidomimetic hematoregulatory compounds, designed based on a pharmacophore model inferred from the structure activity relationships of a peptide SK&F 107647 (1), is reported. These compounds induce a hematopoietic synergistic factor (HSF) which in turn modulates host defense. The compounds may represent novel therapeutic agents in the area of hematoregulation.
- Published
- 2000
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