1. Synthesis of 7 alpha- and 7 beta-spermidinylcholesterol, squalamine analogues.
- Author
-
Choucair B, Dherbomez M, Roussakis C, and El-kihel L
- Subjects
- Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Antifungal Agents chemical synthesis, Antifungal Agents chemistry, Antifungal Agents pharmacology, Bronchial Neoplasms pathology, Carcinoma, Non-Small-Cell Lung pathology, Cell Line, Tumor, Cholestanols chemistry, Cholestanols pharmacology, Drug Screening Assays, Antitumor, Humans, Lung Neoplasms pathology, Cholestanols chemical synthesis
- Abstract
Stereoselective synthesis of squalamine dessulfates analogues, 7 alpha and 7 beta-N-[3N-(4-aminobutyl) aminopropyl]aminocholesterol are reported, using 7 alpha and 7 beta-aminocholesterol as a key intermediate. It's the first example in which the position of spermidine is modified at the steroid ring. These molecules showed a comparable antibacteria and fungi activities to squalamine. Then, they have a cytotoxic activity on a human non-small cell bronchopulmonary carcinoma line (NSCLC-N6).
- Published
- 2004
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