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Your search keyword '"Norisoprenoids chemical synthesis"' showing total 2 results
Start Over Descriptor "Norisoprenoids chemical synthesis" Journal bioorganic medicinal chemistry
2 results on '"Norisoprenoids chemical synthesis"'

1. A simple synthesis of four stereoisomers of roseoside and their inhibitory activity on leukotriene release from mice bone marrow-derived cultured mast cells.

Author

Yajima A, Oono Y, Nakagawa R, Nukada T, and Yabuta G

Subjects
Animals, Bone Marrow, Glucose, Glucosides pharmacology, Mast Cells, Mice, Norisoprenoids pharmacology, Stereoisomerism, Structure-Activity Relationship, Glucosides chemical synthesis, Leukotrienes metabolism, Norisoprenoids chemical synthesis
Abstract

Four stereoisomers of roseoside (vomifoliol glucosides) were synthesized using glucose as a chiral resolving reagent. The four synthetic stereoisomers exhibited inhibitory activity on leukotriene release from mouse bone marrow-derived cultured mast cells (BMCMC). The (6S)-isomers of roseoside were about twice as active as (6R)-isomers.

Published
2009
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2. Synthesis and biological evaluation of novel heterocyclic ionone-like derivatives as anti-inflammatory agents.

Author

Balbi A, Anzaldi M, Mazzei M, Miele M, Bertolotto M, Ottonello L, and Dallegri F

Subjects
Anti-Inflammatory Agents, Non-Steroidal chemistry, Cell Movement drug effects, Cell Survival drug effects, Chemotaxis drug effects, Chemotaxis physiology, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Heterocyclic Compounds, 4 or More Rings chemistry, Humans, Neutrophils chemistry, Neutrophils cytology, Neutrophils drug effects, Norisoprenoids chemistry, Respiratory Burst drug effects, Structure-Activity Relationship, Superoxides metabolism, Anti-Inflammatory Agents, Non-Steroidal chemical synthesis, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Heterocyclic Compounds, 4 or More Rings chemical synthesis, Heterocyclic Compounds, 4 or More Rings pharmacology, Norisoprenoids chemical synthesis, Norisoprenoids pharmacology
Abstract

Five- and six-membered heterocyclic ionone-like derivatives 4-6 have been synthesised in one step and with good yield from the key intermediate 3a and appropriate bifunctional reagents. Four were active as inhibitors of the respiratory burst of human neutrophils without affecting cell viability. The two most active compounds (5a,d) tested in neutrophil migration assays, were also found to be potent inhibitors of neutrophil chemotactic responsiveness. These two molecules could be considered as lead compounds of new drugs which can be an effective tool to treat psoriasis and related neutrophilic dermatoses.

Published
2006
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