1. Synthesis of 1,4,5 trisubstituted γ-lactams via a 3-component cascade reaction.
- Author
-
Petersen MÅ, Mortensen MA, Cohrt AE, Petersen R, Wu P, Fleury-Brégeot N, Morgentin R, Lardy C, Nielsen TE, and Clausen MH
- Subjects
- Catalysis, Combinatorial Chemistry Techniques methods, Molecular Structure, Stereoisomerism, Drug Discovery, Lactams chemical synthesis, Small Molecule Libraries chemical synthesis
- Abstract
A three component one-pot cascade reaction was developed for the synthesis of 1,4,5-trisubstituted γ-lactams. The resulting scaffold can be modified independently at three positions, two of which are conveniently accessed by changing the components of the one-pot reaction. The phases of building block generation, scaffold synthesis and subsequent appendage modification were adapted to library production, which resulted in a screening library of 500 compounds., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2015
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