Search

Your search keyword '"Mamolo, MARIA GRAZIA"' showing total 5 results
Start Over Author "Mamolo, MARIA GRAZIA" Journal bioorganic medicinal chemistry
5 results on '"Mamolo, MARIA GRAZIA"'

1. Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2).

Author

Rossi D, Urbano M, Pedrali A, Serra M, Zampieri D, Mamolo MG, Laggner C, Zanette C, Florio C, Schepmann D, Wuensch B, Azzolina O, and Collina S

Subjects
Alkenes chemistry, Alkenes pharmacology, Amino Alcohols chemistry, Amino Alcohols pharmacology, Animals, Guinea Pigs, Hydrocarbons, Aromatic chemistry, Hydrocarbons, Aromatic pharmacology, Ligands, Models, Molecular, Protein Binding, Rats, Receptors, Opioid metabolism, Structure-Activity Relationship, Amines chemistry, Amines pharmacology, Receptors, sigma metabolism
Abstract

In order to investigate the molecular features involved in sigma receptors (sigma-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards sigma(1)- and sigma(2)-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at micro-opioid, delta-opioid and kappa-opioid receptors. Biological results are herein presented and discussed., (Copyright (c) 2009 Elsevier Ltd. All rights reserved.)

Published
2010
Full Text
View/download PDF

2. Antimycobacterial activity of new 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-one derivatives. Molecular modeling investigations.

Author

Zampieri D, Mamolo MG, Laurini E, Fermeglia M, Posocco P, Pricl S, Banfi E, Scialino G, and Vio L

Subjects
Antitubercular Agents chemical synthesis, Bacterial Proteins antagonists & inhibitors, Computer Simulation, Cytochrome P-450 Enzyme Inhibitors, Microbial Sensitivity Tests, Models, Molecular, Molecular Structure, Mycobacterium tuberculosis physiology, Oxadiazoles chemical synthesis, Protein Binding, Sterol 14-Demethylase, Thermodynamics, Tuberculosis drug therapy, Antitubercular Agents chemistry, Antitubercular Agents pharmacology, Bacterial Proteins metabolism, Cytochrome P-450 Enzyme System metabolism, Mycobacterium tuberculosis drug effects, Oxadiazoles chemistry, Oxadiazoles pharmacology
Abstract

3H-1,3,4-Oxadiazol-2-one derivatives were synthesized and tested for their in vitro antimycobacterial activity. Oxadiazolone derivatives showed an interesting antimycobacterial activity against the reference strain of Mycobacterium tuberculosis H(37)Rv. Molecular modeling investigations were performed and showed that the active compounds possess all necessary features to target the protein active site of the mycobacterial cytochrome P450-dependent sterol 14alpha-demethylase in the sterol biosynthesis pathway as the calculated free energy of binding were in agreement with the corresponding MIC values.

Published
2009
Full Text
View/download PDF

3. Antifungal and antimycobacterial activity of 1-(3,5-diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives.

Author

Zampieri D, Mamolo MG, Laurini E, Scialino G, Banfi E, and Vio L

Subjects
Anti-Bacterial Agents chemistry, Antifungal Agents chemistry, Candida albicans drug effects, Hydrogen chemistry, Imidazoles chemistry, Magnetic Resonance Spectroscopy, Molecular Structure, Mycobacterium tuberculosis drug effects, Structure-Activity Relationship, Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents pharmacology, Antifungal Agents chemical synthesis, Antifungal Agents pharmacology, Imidazoles chemical synthesis, Imidazoles pharmacology, Pyrazoles chemistry
Abstract

1-(3,5-Diaryl-4,5-dihydro-1H-pyrazol-4-yl)-1H-imidazole derivatives were synthesized and tested for their in vitro antifungal and antimycobacterial activities. These imidazole derivatives showed an excellent antifungal activity against a clinical strain of Candida albicans and an interesting antitubercular activity against Mycobacterium tuberculosis H(37)Rv reference strain.

Published
2008
Full Text
View/download PDF

4. Synthesis, antifungal and antimycobacterial activities of new bis-imidazole derivatives, and prediction of their binding to P450(14DM) by molecular docking and MM/PBSA method.

Author

Zampieri D, Mamolo MG, Vio L, Banfi E, Scialino G, Fermeglia M, Ferrone M, and Pricl S

Subjects
Antifungal Agents chemical synthesis, Antifungal Agents chemistry, Antitubercular Agents chemical synthesis, Antitubercular Agents chemistry, Binding Sites, Binding, Competitive, Candida albicans enzymology, Candida glabrata enzymology, Computer Simulation, Cytochrome P-450 Enzyme System chemistry, Cytochrome P-450 Enzyme System drug effects, Imidazoles chemical synthesis, Imidazoles chemistry, Ligands, Microbial Sensitivity Tests, Models, Chemical, Models, Molecular, Molecular Structure, Mycobacterium tuberculosis enzymology, Predictive Value of Tests, Protein Structure, Tertiary, Antifungal Agents pharmacology, Antitubercular Agents pharmacology, Candida albicans drug effects, Candida glabrata drug effects, Imidazoles pharmacology, Mycobacterium tuberculosis drug effects
Abstract

New bis-imidazole derivatives have been synthesized and their antifungal and antimycobacterial activity was determined. Almost all compounds exhibited a moderate to good activity against two clinical isolates of Candida albicans 3038 and Candida glabrata 123. The same compounds showed an interesting killing activity against Mycobacterium tuberculosis H(37)Rv reference strain. Docking procedures combined with molecular dynamics simulations in the MM/PBSA framework of theory were applied to predict the binding mode of all compounds in the binding pocket of the cytochrome P450 14alpha-sterol demethylase (14DM) of C. albicans, for which no ligand-protein crystal structure is currently available. The results obtained in silico showed that the active compounds may interact at the active site of protein, and that their binding free energy values are in agreement with the corresponding experimental activity values.

Published
2007
Full Text
View/download PDF

5. Antimycobacterial activity of new 3-substituted 5-(pyridin-4-yl)-3H-1,3,4-oxadiazol-2-one and 2-thione derivatives. Preliminary molecular modeling investigations.

Author

Mamolo MG, Zampieri D, Vio L, Fermeglia M, Ferrone M, Pricl S, Scialino G, and Banfi E

Subjects
Magnetic Resonance Spectroscopy, Mass Spectrometry, Models, Molecular, Molecular Structure, Antitubercular Agents chemistry, Antitubercular Agents pharmacology, Mycobacterium tuberculosis drug effects
Abstract

3H-1,3,4-Oxadiazole-2-thione and 3H-1,3,4-oxadiazol-2-one derivatives were synthesized and tested for their in vitro antimycobacterial activity. Oxadiazolone derivatives showed an interesting antimycobacterial activity against the tested strain of Mycobacterium tuberculosis H(37)Rv, whereas the corresponding thione derivatives were devoid of activity. Molecular modeling investigations showed that the active compounds may interact at the active site of the mycobacterial cytochrome P450-dependent sterol 14alpha-demethylase in the sterol biosynthesis pathway and that their binding free energy values are in agreement with their MIC values.

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results