1. New diphenyl ethers from a fungus Epicoccum sorghinum L28 and their antifungal activity against phytopathogens
- Author
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Junjie Zhu, Weijia Ding, Yahong Xiong, Jiazhong Li, Haihong Lu, Shengquan Liu, Chunyuan Li, and Ziyang Li
- Subjects
Antifungal Agents ,Microbial Sensitivity Tests ,Colletotrichum musae ,Biochemistry ,Endophyte ,chemistry.chemical_compound ,Structure-Activity Relationship ,Triadimefon ,Ascomycota ,Fusarium ,Drug Discovery ,Fusarium oxysporum ,Colletotrichum ,Organic chemistry ,Molecular Biology ,chemistry.chemical_classification ,biology ,Dose-Response Relationship, Drug ,Molecular Structure ,Guaiol ,Phenyl Ethers ,Organic Chemistry ,Diphenyl ether ,Fatty acid ,biology.organism_classification ,chemistry ,Fermentation - Abstract
The strategy “IEMAHC” (Induction of Endophyte Metabolism by Adding Host Components) was applied to the fermentation of the endophytic fungus Epicoccum sorghinum L28 from Myoporum bontioides by introducing guaiol, an ingredient of M. bontioides, into the cultivation medium, which resulted in the purification of nine new diphenyl ethers, epicoccethers A–I (1–9). Their structures were determined by overall spectroscopic analysis. HPLC-MS analysis revealed that compounds 5–7 were products generated by induction of guaiol. Compounds 6 and 7 are the first members containing an ester moiety formed by the natural long-chain fatty acid and the hydroxyl group in the phenylmethanol unit of the diphenyl ether class. The antifungal activities of compounds 1, 2, and 4–7 against Fusarium oxysporum were 1, 1, 2, 1, 2 and 4 times as high as those of the positive control triadimefon, respectively. Compounds 4 and 5 showed 1.6 times the antifungal activities of triadimefon towards Colletotrichum musae.
- Published
- 2021