1. Further polyoxygenated cembranoids from South China Sea soft coral Sarcophyton ehrenbergi
- Author
-
Heng Li, Geng Li, Li-Gong Yao, Yue-Wei Guo, Wei Tang, and Lin-Fu Liang
- Subjects
South china ,Stereochemistry ,Coral ,Positive control ,01 natural sciences ,Biochemistry ,Mice ,Structure-Activity Relationship ,Drug Discovery ,Cembrane Diterpenes ,Animals ,Seawater ,Molecular Biology ,010405 organic chemistry ,Chemistry ,Tumor Necrosis Factor-alpha ,Spectrum Analysis ,Organic Chemistry ,Absolute configuration ,Sarcophyton ehrenbergi ,Anthozoa ,0104 chemical sciences ,Oxygen ,010404 medicinal & biomolecular chemistry ,RAW 264.7 Cells ,Diterpenes - Abstract
Eleven new cembrane diterpenes, namely, sarcoehrenins A-J (1-9, 11) and (2S,11S,12S)-isosarcophytoxide (10), along with six known compounds, gibberosene B (12), (13S)-cembra-1,3,7,11-tetraen-13-ol (13), (+)-sarcophtol (14), cembrene-C (15), (1R,4R,2E,7E,11E)-cembra-2,7,11-trien-4-ol (16) and (1S,4R,2E,7E,11E)-cembratrien-4-ol (17) were isolated from the soft coral Sarcophyton ehrenbergi collected from Weizhou Island, Beibu Gulf, South China Sea. The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data. The absolute configuration of compound 2 was established by the modified Mosher's method in association with TDDFT ECD calculation, while the absolute configuration of compound 3 was assigned by TDDFT ECD approach. In in vitro bioassays, compounds 13 and 17 showed potent TNF-α inhibitory activities being similar to that of positive control dexamethasone. A preliminary structural-activity relationship was also described.
- Published
- 2020