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Start Over Descriptor "thalidomide analogues" Journal bioorganic & medicinal chemistry letters
1 results on '"thalidomide analogues"'

1. Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide

Author

Machado, Alexandre Légora, Lima, Lı́dia Moreira, Araújo-Jr, João Xavier, Fraga, Carlos Alberto M., Gonçalves Koatz, Vera Lúcia, and Barreiro, Eliezer J.

Subjects
*ANTI-inflammatory agents, *ANTIPYRETICS, *INFLAMMATION, *ACETANILIDE
Abstract

Abstract: As part of an ongoing effort to develop new thalidomide analogues as antiinflammatory lead-candidates, this paper describes the synthesis and antiinflammatory activity of novel N-phenyl-phthalimide functionalized derivatives (4a–d, 5a,b, 6a,b). The target compounds were assayed in an acute lung inflammatory model and all compounds were able to inhibit TNF-α production and subsequent neutrophil recruitment in the LPS-acute lung inflammatory model. [Copyright &y& Elsevier]

Published
2005
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