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Your search keyword '"Ye, Yunpeng"' showing total 4 results
Start Over Author "Ye, Yunpeng" Journal bioorganic & medicinal chemistry letters
4 results on '"Ye, Yunpeng"'

4. Near-infrared fluorescent divalent RGD ligand for integrin αvβ3-targeted optical imaging

Author

Ye, Yunpeng, Akers, Walter, Xu, Baogang, Bloch, Sharon, Odonkor, Charles, and Achilefu, Samuel

Subjects
*LIGAND binding (Biochemistry), *CARBOXYLIC acids, *LABORATORY mice, *CYANINES, *CANCER treatment, *INTEGRINS, *IMAGING systems, *FLUORESCENCE spectroscopy
Abstract

Abstract: A new near-infrared fluorescent compound containing two cyclic RGD motifs, cypate-[c(RGDfK)]2 (1), was synthesized based on a carbocyanine fluorophore bearing two carboxylic acid groups (cypate) for integrin αvβ3-targeting. Compared with its monovalent counterpart cypate-c(RGDfK) (2), 1 exhibited remarkable improvements in integrin αvβ3 binding affinity and tumor uptake in nude mice of A549. The results suggest that cypate-linked divalent ligands can serve as an important molecular platform for exploring receptor-targeted optical imaging and treatment of various diseases. [Copyright &y& Elsevier]

Published
2012
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