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Start Over Author "Xing, Charles" Journal bioorganic & medicinal chemistry letters
5 results on '"Xing, Charles"'

1. Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease

Author

Buzard, Daniel J., Han, Sangdon, Lopez, Luis, Kawasaki, Andrew, Moody, Jeanne, Thoresen, Lars, Ullman, Brett, Lehmann, Juerg, Calderon, Imelda, Zhu, Xiuwen, Gharbaoui, Tawfik, Sengupta, Dipanjan, Krishnan, Ashwin, Gao, Yinghong, Edwards, Jeff, Barden, Jeremy, Morgan, Michael, Usmani, Khawja, Chen, Chuan, Sadeque, Abu, Thatte, Jayant, Solomon, Michelle, Fu, Lixia, Whelan, Kevin, Liu, Ling, Al-Shamma, Hussien, Gatlin, Joel, Le, Minh, Xing, Charles, Espinola, Sheryll, and Jones, Robert M.

Published
2012
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2. Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P 1 agonists

Author

Buzard, Daniel, Han, Sangdon, Thoresen, Lars, Moody, Jeanne, Lopez, Luis, Kawasaki, Andrew, Schrader, Thomas, Sage, Carleton, Gao, Yinghong, Edwards, Jeff, Barden, Jeremy, Thatte, Jayant, Fu, Lixia, Solomon, Michelle, Liu, Ling, Al-Shamma, Hussien, Gatlin, Joel, Le, Minh, Xing, Charles, Espinola, Sheryll, and Jones, Robert M.

Published
2011
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3. Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control

Author

Semple, Graeme, Ren, Albert, Fioravanti, Beatriz, Pereira, Guillherme, Calderon, Imelda, Choi, Karoline, Xiong, Yifeng, Shin, Young-Jun, Gharbaoui, Tawfik, Sage, Carleton R., Morgan, Michael, Xing, Charles, Chu, Zhi-Liang, Leonard, James N., Grottick, Andrew J., Al-Shamma, Hussein, Liang, Yin, Demarest, Keith T., and Jones, Robert M.

Published
2011
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4. Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P1 agonists

Author

Buzard, Daniel, primary, Han, Sangdon, additional, Thoresen, Lars, additional, Moody, Jeanne, additional, Lopez, Luis, additional, Kawasaki, Andrew, additional, Schrader, Thomas, additional, Sage, Carleton, additional, Gao, Yinghong, additional, Edwards, Jeff, additional, Barden, Jeremy, additional, Thatte, Jayant, additional, Fu, Lixia, additional, Solomon, Michelle, additional, Liu, Ling, additional, Al-Shamma, Hussien, additional, Gatlin, Joel, additional, Le, Minh, additional, Xing, Charles, additional, Espinola, Sheryll, additional, and Jones, Robert M., additional

Published
2011
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5. Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P1 agonists

Author

Buzard, Daniel, Han, Sangdon, Thoresen, Lars, Moody, Jeanne, Lopez, Luis, Kawasaki, Andrew, Schrader, Thomas, Sage, Carleton, Gao, Yinghong, Edwards, Jeff, Barden, Jeremy, Thatte, Jayant, Fu, Lixia, Solomon, Michelle, Liu, Ling, Al-Shamma, Hussien, Gatlin, Joel, Le, Minh, Xing, Charles, and Espinola, Sheryll

Subjects
*PHARMACEUTICAL research, *DRUG synergism, *BUTYRIC acid, *LYMPHOPENIA, *AUTOIMMUNE disease treatment, *SPHINGOSINE, *PHOSPHATES, *DRUG receptors
Abstract

Abstract: S1P1 receptor driven lymphopenia has proven utility in the treatment of an array of autoimmune disease states. As a part of our efforts to develop potent and selective S1P1 receptor agonists, we have identified a novel chemical series of 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acid S1P1 receptor agonists. [Copyright &y& Elsevier]

Published
2011
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