1. Sulfamic and succinic acid derivatives of 25-OH-PPD and their activities to MCF-7, A-549, HCT-116, and BGC-823 cell lines.
- Author
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Zhou, Wu-Xi, Cao, Jia-Qing, Wang, Xu-De, Guo, Jun-Hui, and Zhao, Yu-Qing
- Subjects
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CELL culture , *SULFAMIC acid , *ANTINEOPLASTIC agents , *HYDROXYPROLINE , *SUCCINIC acid , *PHARMACOKINETICS - Abstract
In the search for new anti-tumor agents with higher potency than our previously identified compound 1 (25-OH-PPD, 25-hydroxyprotopanaxadiol), 12 novel sulfamic and succinic acid derivatives that could improve water solubility and contribute to good drug potency and pharmacokinetic profiles were designed and synthesized. Their in vitro anti-tumor activities in MCF-7, A-549, HCT-116, and BGC-823 cell lines and one normal cell line were tested by standard MTT assay. Results showed that compared with compound 1, compounds 2, 3, and 7 exhibited higher cytotoxic activity on A-549 and BGC-823 cell lines, together with lower toxicity in the normal cell. In particular, compound 2 exhibited the best anti-tumor activity in the in vitro assays, which may provide valuable data for the research and development of new anti-tumor agents. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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