1. Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position
- Author
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Fnu Sangita, Sonali Rudra, Smita Singhal, Pragya Bhateja, Arti Gujrati, Tarun Mathur, Ashok Rattan, Mohammed Salman, Manisha Pandya, and Biswajit Das
- Subjects
Chemistry, Pharmaceutical ,Clinical Biochemistry ,Nitro compound ,Pharmaceutical Science ,chemistry.chemical_element ,Microbial Sensitivity Tests ,Primary alcohol ,Biochemistry ,Chemical synthesis ,Mass Spectrometry ,Piperazines ,Methicillin ,chemistry.chemical_compound ,Thiocarbamates ,Acetamides ,Drug Resistance, Bacterial ,Gram-Negative Bacteria ,Drug Discovery ,Organic chemistry ,Methylene ,Piperazine ,Molecular Biology ,Oxazolidinones ,Antibacterial agent ,chemistry.chemical_classification ,Organic Chemistry ,Linezolid ,Temperature ,Sulfur ,Combinatorial chemistry ,Anti-Bacterial Agents ,Models, Chemical ,chemistry ,Drug Design ,Molecular Medicine ,Antibacterial activity ,Lead compound - Abstract
Novel oxazolidinone derivatives of the lead compound RBx 8700, containing methylene oxygen- and methylene sulfur-linked substituents at the C5-position, were synthesized. Antibacterial screening of these compounds against a panel of resistant and susceptible Gram-positive and fastidious Gram-negative bacteria gave compounds 2 and 4 as new antibacterial agents.
- Published
- 2007
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