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Start Over Author "Shibuya, Satoshi" Journal bioorganic & medicinal chemistry letters
3 results on '"Shibuya, Satoshi"'

3. <atl>Synthesis of Sordaricin Analogues as Potent Antifungal Agents against Candida albicans

Author

Kaneko, Satoru, Uchida, Takuya, Shibuya, Satoshi, Honda, Takeshi, Kawamoto, Isao, Harasaki, Tamako, Fukuoka, Takashi, and Konosu, Toshiyuki

Subjects
*CYCLOHEXANE, *AMINE oxidase, *ANTIFUNGAL agents, *CANDIDA albicans
Abstract

Sordaricin derivatives possessing a cyclohexane ring appendage attached via an ether, thioether, amine, oxime, ester or amide linkage were synthesized and their antifungal activity was evaluated in vitro. Compounds containing a thioether bond or an oxime bond as a linkage exhibited potent MICs (≤0.125 μg/mL) against four Candida albicans strains including azole-low-susceptible strains. They were also active (MIC ≤0.125 μg/mL) against Candida glabrata. Their in vivo efficacy was confirmed in a murine intravenous infection model with Candida albicans. [Copyright &y& Elsevier]

Published
2002
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